node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Fen1 | T1INI8_STRMM | T1J246 | T1INI8 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family. | 0.994 |
Fen1 | T1IZP4_STRMM | T1J246 | T1IZP4 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA ligase. | 0.927 |
Fen1 | T1J406_STRMM | T1J246 | T1J406 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein. | 0.836 |
Fen1 | T1J442_STRMM | T1J246 | T1J442 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Ku domain-containing protein. | 0.834 |
Fen1 | T1J499_STRMM | T1J246 | T1J499 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | FHA_2 domain-containing protein. | 0.477 |
Fen1 | T1J7P5_STRMM | T1J246 | T1J7P5 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. | 0.901 |
Fen1 | T1J9L4_STRMM | T1J246 | T1J9L4 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein. | 0.933 |
Fen1 | T1JBC6_STRMM | T1J246 | T1JBC6 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA ligase. | 0.925 |
Fen1 | T1JGW4_STRMM | T1J246 | T1JGW4 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.999 |
Fen1 | T1JNH2_STRMM | T1J246 | T1JNH2 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | BRCT domain-containing protein. | 0.817 |
T1INI8_STRMM | Fen1 | T1INI8 | T1J246 | DNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.994 |
T1INI8_STRMM | T1IZP4_STRMM | T1INI8 | T1IZP4 | DNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family. | DNA ligase. | 0.750 |
T1INI8_STRMM | T1J406_STRMM | T1INI8 | T1J406 | DNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family. | Uncharacterized protein. | 0.965 |
T1INI8_STRMM | T1J442_STRMM | T1INI8 | T1J442 | DNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family. | Ku domain-containing protein. | 0.961 |
T1INI8_STRMM | T1J499_STRMM | T1INI8 | T1J499 | DNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family. | FHA_2 domain-containing protein. | 0.878 |
T1INI8_STRMM | T1J7P5_STRMM | T1INI8 | T1J7P5 | DNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family. | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. | 0.903 |
T1INI8_STRMM | T1J9L4_STRMM | T1INI8 | T1J9L4 | DNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family. | Uncharacterized protein. | 0.941 |
T1INI8_STRMM | T1JBC6_STRMM | T1INI8 | T1JBC6 | DNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family. | DNA ligase. | 0.889 |
T1INI8_STRMM | T1JGW4_STRMM | T1INI8 | T1JGW4 | DNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.999 |
T1INI8_STRMM | T1JNH2_STRMM | T1INI8 | T1JNH2 | DNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family. | BRCT domain-containing protein. | 0.871 |