STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC101344363Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (251 aa)    
Predicted Functional Partners:
LOC101349284
Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.
    
0.988
LOC101348204
Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.
    
0.988
LOC101356451
Transitional endoplasmic reticulum ATPase; Belongs to the AAA ATPase family.
   
 0.975
LOC101342025
E3 ubiquitin-protein ligase synoviolin isoform X1.
    
 0.969
LOC101345180
Ubiquitin recognition factor in ER-associated degradation protein 1 isoform X1.
   
 
 0.967
LOC101357354
E3 ubiquitin-protein ligase AMFR isoform X1.
    
 0.959
LOC101342353
UBX domain-containing protein 1 isoform X1.
    
 0.958
LOC101340706
78 kDa glucose-regulated protein; Belongs to the heat shock protein 70 family.
   
 0.949
LOC101341616
Protein sel-1 homolog 1 isoform X1.
   
 0.949
LOC101342136
Endoplasmic reticulum lectin 1 isoform X1.
    
 0.941
Your Current Organism:
Trichechus manatus
NCBI taxonomy Id: 127582
Other names: Florida manatee, T. manatus latirostris, Trichechus manatus latirostris
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.