STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC101341962E3 SUMO-protein ligase EGR2 isoform X1. (475 aa)    
Predicted Functional Partners:
LOC101361283
Early growth response protein 3.
  
0.976
LOC101344282
CREB-binding protein.
    
 0.919
LOC101349614
Histone acetyltransferase p300.
    
 0.919
LOC101344391
NGFI-A-binding protein 2.
   
 0.894
LOC101360593
Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family.
   
0.853
LOC101355201
Protein fosB.
   
 0.760
LOC101357016
Proto-oncogene c-Fos.
   
 0.710
LOC101351795
NGFI-A-binding protein 1 isoform X1.
    
 0.701
LOC101355073
Periaxin.
    
 0.674
LOC101351968
chromodomain-helicase-DNA-binding protein 4 isoform X1.
   
 0.669
Your Current Organism:
Trichechus manatus
NCBI taxonomy Id: 127582
Other names: Florida manatee, T. manatus latirostris, Trichechus manatus latirostris
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.