STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC105755980Insulin. (156 aa)    
Predicted Functional Partners:
LOC101340940
Insulin-degrading enzyme isoform X1; Belongs to the peptidase M16 family.
    
 0.867
LOC105756396
Insulin receptor-like.
    
 0.808
LOC101360415
Tyrosine-protein kinase receptor.
    
 0.808
LOC101352828
Appetite-regulating hormone.
     
 0.794
LOC101360391
Nardilysin isoform X1.
    
 0.751
LOC111819813
Insulin-like growth factor 1 receptor isoform X1.
    
 0.744
LOC101355333
Tyrosine-protein kinase receptor.
    
 0.744
LOC101351640
Tyrosine-protein kinase receptor.
    
 0.661
LOC101355971
Pro-epidermal growth factor.
     
 0.637
LOC101357146
Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]
      
 0.632
Your Current Organism:
Trichechus manatus
NCBI taxonomy Id: 127582
Other names: Florida manatee, T. manatus latirostris, Trichechus manatus latirostris
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