STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC101347137Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (469 aa)    
Predicted Functional Partners:
LOC101353622
Nicastrin isoform X1.
   
 0.999
LOC101348306
Gamma-secretase subunit PEN-2.
    
 0.998
LOC101356799
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
  
 
0.998
LOC101351897
Catenin beta-1.
    
 0.982
LOC101356207
Gamma-secretase subunit APH-1B isoform X1.
   
 0.973
LOC101353716
Gamma-secretase subunit APH-1A.
   
 0.973
LOC101348816
Neurogenic locus notch homolog protein 1.
    
 0.972
LOC101349186
Glycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily.
   
 0.952
LOC101352446
Serine/threonine-protein kinase/endoribonuclease IRE1.
    
 0.922
LOC101354392
Inositol 1,4,5-trisphosphate receptor type 3.
    
 0.916
Your Current Organism:
Trichechus manatus
NCBI taxonomy Id: 127582
Other names: Florida manatee, T. manatus latirostris, Trichechus manatus latirostris
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.