node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LOC101341332 | LOC101346617 | A0A2Y9DPP1 | A0A2Y9RJ36 | E3 SUMO-protein ligase PIAS4. | Baculoviral IAP repeat-containing protein 6 isoform X1. | 0.576 |
LOC101341332 | LOC101351852 | A0A2Y9DPP1 | A0A2Y9R5B9 | E3 SUMO-protein ligase PIAS4. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.933 |
LOC101341332 | LOC101353409 | A0A2Y9DPP1 | A0A2Y9R335 | E3 SUMO-protein ligase PIAS4. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.738 |
LOC101341332 | LOC101357287 | A0A2Y9DPP1 | A0A2Y9R1E2 | E3 SUMO-protein ligase PIAS4. | Probable E3 ubiquitin-protein ligase HERC1 isoform X1. | 0.619 |
LOC101341332 | LOC111822625 | A0A2Y9DPP1 | A0A2Y9RS31 | E3 SUMO-protein ligase PIAS4. | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.514 |
LOC101341688 | LOC101357287 | A0A2Y9RPG7 | A0A2Y9R1E2 | Uncharacterized protein KIAA1109 homolog isoform X1. | Probable E3 ubiquitin-protein ligase HERC1 isoform X1. | 0.604 |
LOC101346617 | LOC101341332 | A0A2Y9RJ36 | A0A2Y9DPP1 | Baculoviral IAP repeat-containing protein 6 isoform X1. | E3 SUMO-protein ligase PIAS4. | 0.576 |
LOC101346617 | LOC101351852 | A0A2Y9RJ36 | A0A2Y9R5B9 | Baculoviral IAP repeat-containing protein 6 isoform X1. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.406 |
LOC101346617 | LOC101353409 | A0A2Y9RJ36 | A0A2Y9R335 | Baculoviral IAP repeat-containing protein 6 isoform X1. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.483 |
LOC101346617 | LOC101354044 | A0A2Y9RJ36 | A0A2Y9D7N9 | Baculoviral IAP repeat-containing protein 6 isoform X1. | ranBP2-like and GRIP domain-containing protein 4 isoform X1. | 0.957 |
LOC101346617 | LOC101355836 | A0A2Y9RJ36 | A0A2Y9QGJ3 | Baculoviral IAP repeat-containing protein 6 isoform X1. | E3 ubiquitin-protein ligase MYCBP2 isoform X1. | 0.590 |
LOC101346617 | LOC101357287 | A0A2Y9RJ36 | A0A2Y9R1E2 | Baculoviral IAP repeat-containing protein 6 isoform X1. | Probable E3 ubiquitin-protein ligase HERC1 isoform X1. | 0.618 |
LOC101346639 | LOC101351852 | A0A2Y9QW84 | A0A2Y9R5B9 | Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.992 |
LOC101346639 | LOC101357287 | A0A2Y9QW84 | A0A2Y9R1E2 | Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. | Probable E3 ubiquitin-protein ligase HERC1 isoform X1. | 0.516 |
LOC101346639 | LOC101357552 | A0A2Y9QW84 | A0A2Y9QTP0 | Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. | Neuralized-like protein 4. | 0.457 |
LOC101351852 | LOC101341332 | A0A2Y9R5B9 | A0A2Y9DPP1 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | E3 SUMO-protein ligase PIAS4. | 0.933 |
LOC101351852 | LOC101346617 | A0A2Y9R5B9 | A0A2Y9RJ36 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Baculoviral IAP repeat-containing protein 6 isoform X1. | 0.406 |
LOC101351852 | LOC101346639 | A0A2Y9R5B9 | A0A2Y9QW84 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. | 0.992 |
LOC101351852 | LOC101357287 | A0A2Y9R5B9 | A0A2Y9R1E2 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Probable E3 ubiquitin-protein ligase HERC1 isoform X1. | 0.554 |
LOC101353409 | LOC101341332 | A0A2Y9R335 | A0A2Y9DPP1 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | E3 SUMO-protein ligase PIAS4. | 0.738 |