STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC101351511Disintegrin and metalloproteinase domain-containing protein 22 isoform X6. (964 aa)    
Predicted Functional Partners:
LOC101344682
Leucine-rich glioma-inactivated protein 1 isoform X1.
    
 0.956
LOC101360753
Disks large homolog 4 isoform X2; Belongs to the MAGUK family.
   
 0.890
LOC101361510
Leucine-rich repeat LGI family member 2.
     
 0.818
LOC101352833
Leucine-rich repeat LGI family member 4.
     
 0.773
LOC101351914
14-3-3 protein zeta/delta; Belongs to the 14-3-3 family.
    
 
 0.766
LOC101353227
Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
   
 
 0.707
LOC101358415
Leucine-rich repeat LGI family member 3.
   
 
 0.699
LOC101355698
Disintegrin and metalloproteinase domain-containing protein 23.
  
 
0.692
LOC101352480
Disks large homolog 2 isoform X1.
   
 0.625
LOC101353387
Disks large homolog 1 isoform X1; Belongs to the MAGUK family.
   
 0.625
Your Current Organism:
Trichechus manatus
NCBI taxonomy Id: 127582
Other names: Florida manatee, T. manatus latirostris, Trichechus manatus latirostris
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.