node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LOC101340919 | LOC101346218 | A0A2Y9RCD6 | A0A2Y9DJL1 | LON peptidase N-terminal domain and RING finger protein 1 isoform X1. | Ubiquitin-conjugating enzyme E2 variant 2 isoform X1. | 0.490 |
LOC101340919 | LOC101348454 | A0A2Y9RCD6 | A0A2Y9DZC2 | LON peptidase N-terminal domain and RING finger protein 1 isoform X1. | Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. | 0.450 |
LOC101340919 | LOC101351365 | A0A2Y9RCD6 | A0A2Y9RL08 | LON peptidase N-terminal domain and RING finger protein 1 isoform X1. | E3 ubiquitin-protein ligase TRIP12 isoform X1. | 0.563 |
LOC101340919 | LOC101353409 | A0A2Y9RCD6 | A0A2Y9R335 | LON peptidase N-terminal domain and RING finger protein 1 isoform X1. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.490 |
LOC101340919 | LOC101356605 | A0A2Y9RCD6 | A0A2Y9QHQ0 | LON peptidase N-terminal domain and RING finger protein 1 isoform X1. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.456 |
LOC101340919 | LOC101360405 | A0A2Y9RCD6 | A0A2Y9DL88 | LON peptidase N-terminal domain and RING finger protein 1 isoform X1. | BRCA1-associated RING domain protein 1 isoform X1. | 0.468 |
LOC101340919 | LOC101361445 | A0A2Y9RCD6 | A0A2Y9DT81 | LON peptidase N-terminal domain and RING finger protein 1 isoform X1. | TP53-binding protein 1 isoform X2. | 0.548 |
LOC101340919 | LOC101361963 | A0A2Y9RCD6 | A0A2Y9RRG2 | LON peptidase N-terminal domain and RING finger protein 1 isoform X1. | ubiquitin-60S ribosomal protein L40. | 0.484 |
LOC101340919 | LOC101361983 | A0A2Y9RCD6 | A0A2Y9D7Q5 | LON peptidase N-terminal domain and RING finger protein 1 isoform X1. | ubiquitin-40S ribosomal protein S27a. | 0.549 |
LOC101340919 | LOC111822114 | A0A2Y9RCD6 | A0A2Y9RTQ0 | LON peptidase N-terminal domain and RING finger protein 1 isoform X1. | polyubiquitin-C. | 0.484 |
LOC101346218 | LOC101340919 | A0A2Y9DJL1 | A0A2Y9RCD6 | Ubiquitin-conjugating enzyme E2 variant 2 isoform X1. | LON peptidase N-terminal domain and RING finger protein 1 isoform X1. | 0.490 |
LOC101346218 | LOC101348454 | A0A2Y9DJL1 | A0A2Y9DZC2 | Ubiquitin-conjugating enzyme E2 variant 2 isoform X1. | Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. | 0.963 |
LOC101346218 | LOC101353409 | A0A2Y9DJL1 | A0A2Y9R335 | Ubiquitin-conjugating enzyme E2 variant 2 isoform X1. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.832 |
LOC101346218 | LOC101356605 | A0A2Y9DJL1 | A0A2Y9QHQ0 | Ubiquitin-conjugating enzyme E2 variant 2 isoform X1. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.440 |
LOC101346218 | LOC101360405 | A0A2Y9DJL1 | A0A2Y9DL88 | Ubiquitin-conjugating enzyme E2 variant 2 isoform X1. | BRCA1-associated RING domain protein 1 isoform X1. | 0.554 |
LOC101346218 | LOC101361445 | A0A2Y9DJL1 | A0A2Y9DT81 | Ubiquitin-conjugating enzyme E2 variant 2 isoform X1. | TP53-binding protein 1 isoform X2. | 0.692 |
LOC101346218 | LOC101361963 | A0A2Y9DJL1 | A0A2Y9RRG2 | Ubiquitin-conjugating enzyme E2 variant 2 isoform X1. | ubiquitin-60S ribosomal protein L40. | 0.889 |
LOC101346218 | LOC101361983 | A0A2Y9DJL1 | A0A2Y9D7Q5 | Ubiquitin-conjugating enzyme E2 variant 2 isoform X1. | ubiquitin-40S ribosomal protein S27a. | 0.969 |
LOC101346218 | LOC111822114 | A0A2Y9DJL1 | A0A2Y9RTQ0 | Ubiquitin-conjugating enzyme E2 variant 2 isoform X1. | polyubiquitin-C. | 0.889 |
LOC101348454 | LOC101340919 | A0A2Y9DZC2 | A0A2Y9RCD6 | Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. | LON peptidase N-terminal domain and RING finger protein 1 isoform X1. | 0.450 |