node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LOC101341680 | LOC101343371 | A0A2Y9E2D0 | A0A2Y9RPI8 | Serine/threonine-protein kinase ATR isoform X1; Belongs to the PI3/PI4-kinase family. | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.966 |
LOC101341680 | LOC101345229 | A0A2Y9E2D0 | A0A2Y9RPW2 | Serine/threonine-protein kinase ATR isoform X1; Belongs to the PI3/PI4-kinase family. | Werner syndrome ATP-dependent helicase isoform X1. | 0.994 |
LOC101341680 | LOC101345463 | A0A2Y9E2D0 | A0A2Y9DSE0 | Serine/threonine-protein kinase ATR isoform X1; Belongs to the PI3/PI4-kinase family. | Serine/threonine-protein kinase Chk1 isoform X1; Belongs to the protein kinase superfamily. | 0.998 |
LOC101341680 | LOC101346880 | A0A2Y9E2D0 | A0A2Y9QJ75 | Serine/threonine-protein kinase ATR isoform X1; Belongs to the PI3/PI4-kinase family. | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. | 0.924 |
LOC101341680 | LOC101351852 | A0A2Y9E2D0 | A0A2Y9R5B9 | Serine/threonine-protein kinase ATR isoform X1; Belongs to the PI3/PI4-kinase family. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.979 |
LOC101341680 | LOC101355206 | A0A2Y9E2D0 | A0A2Y9RMG5 | Serine/threonine-protein kinase ATR isoform X1; Belongs to the PI3/PI4-kinase family. | Serine-protein kinase ATM isoform X1. | 0.994 |
LOC101341680 | LOC101355635 | A0A2Y9E2D0 | A0A2Y9E2A6 | Serine/threonine-protein kinase ATR isoform X1; Belongs to the PI3/PI4-kinase family. | DNA repair protein RAD50 isoform X1. | 0.933 |
LOC101341680 | LOC101356605 | A0A2Y9E2D0 | A0A2Y9QHQ0 | Serine/threonine-protein kinase ATR isoform X1; Belongs to the PI3/PI4-kinase family. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.987 |
LOC101341680 | LOC101359759 | A0A2Y9E2D0 | A0A2Y9S0H5 | Serine/threonine-protein kinase ATR isoform X1; Belongs to the PI3/PI4-kinase family. | Serine/threonine-protein kinase Chk2. | 0.995 |
LOC101341680 | LOC111821652 | A0A2Y9E2D0 | A0A2Y9RMH1 | Serine/threonine-protein kinase ATR isoform X1; Belongs to the PI3/PI4-kinase family. | Serine-protein kinase ATM-like; Belongs to the PI3/PI4-kinase family. | 0.994 |
LOC101343371 | LOC101341680 | A0A2Y9RPI8 | A0A2Y9E2D0 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | Serine/threonine-protein kinase ATR isoform X1; Belongs to the PI3/PI4-kinase family. | 0.966 |
LOC101343371 | LOC101345229 | A0A2Y9RPI8 | A0A2Y9RPW2 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | Werner syndrome ATP-dependent helicase isoform X1. | 0.991 |
LOC101343371 | LOC101345463 | A0A2Y9RPI8 | A0A2Y9DSE0 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | Serine/threonine-protein kinase Chk1 isoform X1; Belongs to the protein kinase superfamily. | 0.766 |
LOC101343371 | LOC101346880 | A0A2Y9RPI8 | A0A2Y9QJ75 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. | 0.999 |
LOC101343371 | LOC101351852 | A0A2Y9RPI8 | A0A2Y9R5B9 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.626 |
LOC101343371 | LOC101355206 | A0A2Y9RPI8 | A0A2Y9RMG5 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | Serine-protein kinase ATM isoform X1. | 0.992 |
LOC101343371 | LOC101355635 | A0A2Y9RPI8 | A0A2Y9E2A6 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | DNA repair protein RAD50 isoform X1. | 0.999 |
LOC101343371 | LOC101356605 | A0A2Y9RPI8 | A0A2Y9QHQ0 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.981 |
LOC101343371 | LOC101359759 | A0A2Y9RPI8 | A0A2Y9S0H5 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | Serine/threonine-protein kinase Chk2. | 0.781 |
LOC101343371 | LOC111821652 | A0A2Y9RPI8 | A0A2Y9RMH1 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | Serine-protein kinase ATM-like; Belongs to the PI3/PI4-kinase family. | 0.992 |