node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LOC101341753 | LOC101345229 | A0A2Y9RAT3 | A0A2Y9RPW2 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | Werner syndrome ATP-dependent helicase isoform X1. | 0.787 |
LOC101341753 | LOC101348269 | A0A2Y9RAT3 | A0A2Y9RAR8 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. | 0.896 |
LOC101341753 | LOC101348404 | A0A2Y9RAT3 | A0A2Y9EB88 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | TERF1-interacting nuclear factor 2 isoform X1. | 0.755 |
LOC101341753 | LOC101348804 | A0A2Y9RAT3 | A0A2Y9S0W1 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | Telomeric repeat-binding factor 2-interacting protein 1. | 0.553 |
LOC101341753 | LOC101354585 | A0A2Y9RAT3 | A0A2Y9R5A2 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | CST complex subunit CTC1. | 0.506 |
LOC101341753 | LOC101354652 | A0A2Y9RAT3 | A0A2Y9QL25 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | LOW QUALITY PROTEIN: adrenocortical dysplasia protein homolog. | 0.888 |
LOC101341753 | LOC101355763 | A0A2Y9RAT3 | A0A2Y9QQ11 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. | 0.743 |
LOC101341753 | LOC101359378 | A0A2Y9RAT3 | A0A2Y9DT76 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | H/ACA ribonucleoprotein complex subunit 3. | 0.895 |
LOC101341753 | LOC101360529 | A0A2Y9RAT3 | A0A2Y9RQ54 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | Protection of telomeres protein 1. | 0.953 |
LOC101345229 | LOC101341753 | A0A2Y9RPW2 | A0A2Y9RAT3 | Werner syndrome ATP-dependent helicase isoform X1. | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | 0.787 |
LOC101345229 | LOC101348404 | A0A2Y9RPW2 | A0A2Y9EB88 | Werner syndrome ATP-dependent helicase isoform X1. | TERF1-interacting nuclear factor 2 isoform X1. | 0.655 |
LOC101345229 | LOC101354652 | A0A2Y9RPW2 | A0A2Y9QL25 | Werner syndrome ATP-dependent helicase isoform X1. | LOW QUALITY PROTEIN: adrenocortical dysplasia protein homolog. | 0.930 |
LOC101345229 | LOC101355763 | A0A2Y9RPW2 | A0A2Y9QQ11 | Werner syndrome ATP-dependent helicase isoform X1. | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. | 0.756 |
LOC101345229 | LOC101360529 | A0A2Y9RPW2 | A0A2Y9RQ54 | Werner syndrome ATP-dependent helicase isoform X1. | Protection of telomeres protein 1. | 0.972 |
LOC101346186 | LOC101348404 | A0A2Y9E8J4 | A0A2Y9EB88 | Tripeptidyl-peptidase 1. | TERF1-interacting nuclear factor 2 isoform X1. | 0.728 |
LOC101346186 | LOC101348804 | A0A2Y9E8J4 | A0A2Y9S0W1 | Tripeptidyl-peptidase 1. | Telomeric repeat-binding factor 2-interacting protein 1. | 0.588 |
LOC101346186 | LOC101354585 | A0A2Y9E8J4 | A0A2Y9R5A2 | Tripeptidyl-peptidase 1. | CST complex subunit CTC1. | 0.435 |
LOC101346186 | LOC101355763 | A0A2Y9E8J4 | A0A2Y9QQ11 | Tripeptidyl-peptidase 1. | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. | 0.708 |
LOC101346186 | LOC101360529 | A0A2Y9E8J4 | A0A2Y9RQ54 | Tripeptidyl-peptidase 1. | Protection of telomeres protein 1. | 0.755 |
LOC101348269 | LOC101341753 | A0A2Y9RAR8 | A0A2Y9RAT3 | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | 0.896 |