msrA protein (Cesiribacter andamanensis) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

msrA

Peptide methionine sulfoxide reductase MsrA. (131 aa)

Predicted Functional Partners:

msrB_1

0.985

polA

0.867

msrB_3

0.842

EMR04222.1

0.831

EMR03007.1

0.831

EMR03008.1

0.831

resA_2

0.831

EMR01013.1

0.831

msrB_2

0.786

EMR03800.1

0.731

Your Current Organism:

Cesiribacter andamanensis

NCBI taxonomy Id: 1279009
Other names: C. andamanensis AMV16, Cesiribacter andamanensis AMV16, Flexibacter sp. AMV16

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EMR01013.1	EMR03800.1	ADICEAN_03862	ADICEAN_01041	Hypothetical protein.	Thiol:disulfide interchange protein precursor.	0.807
EMR01013.1	msrA	ADICEAN_03862	ADICEAN_01530	Hypothetical protein.	Peptide methionine sulfoxide reductase MsrA.	0.831
EMR01013.1	msrB_1	ADICEAN_03862	ADICEAN_00373	Hypothetical protein.	Peptide methionine sulfoxide reductase MsrB.	0.400
EMR01013.1	msrB_2	ADICEAN_03862	ADICEAN_01413	Hypothetical protein.	Peptide methionine sulfoxide reductase MsrB.	0.400
EMR01013.1	msrB_3	ADICEAN_03862	ADICEAN_01414	Hypothetical protein.	Peptide methionine sulfoxide reductase MsrB.	0.400
EMR03007.1	EMR03008.1	ADICEAN_01856	ADICEAN_01857	Hypothetical protein.	Hypothetical protein.	0.651
EMR03007.1	EMR03800.1	ADICEAN_01856	ADICEAN_01041	Hypothetical protein.	Thiol:disulfide interchange protein precursor.	0.807
EMR03007.1	msrA	ADICEAN_01856	ADICEAN_01530	Hypothetical protein.	Peptide methionine sulfoxide reductase MsrA.	0.831
EMR03007.1	msrB_1	ADICEAN_01856	ADICEAN_00373	Hypothetical protein.	Peptide methionine sulfoxide reductase MsrB.	0.400
EMR03007.1	msrB_2	ADICEAN_01856	ADICEAN_01413	Hypothetical protein.	Peptide methionine sulfoxide reductase MsrB.	0.400
EMR03007.1	msrB_3	ADICEAN_01856	ADICEAN_01414	Hypothetical protein.	Peptide methionine sulfoxide reductase MsrB.	0.400
EMR03008.1	EMR03007.1	ADICEAN_01857	ADICEAN_01856	Hypothetical protein.	Hypothetical protein.	0.651
EMR03008.1	EMR03800.1	ADICEAN_01857	ADICEAN_01041	Hypothetical protein.	Thiol:disulfide interchange protein precursor.	0.807
EMR03008.1	msrA	ADICEAN_01857	ADICEAN_01530	Hypothetical protein.	Peptide methionine sulfoxide reductase MsrA.	0.831
EMR03008.1	msrB_1	ADICEAN_01857	ADICEAN_00373	Hypothetical protein.	Peptide methionine sulfoxide reductase MsrB.	0.400
EMR03008.1	msrB_2	ADICEAN_01857	ADICEAN_01413	Hypothetical protein.	Peptide methionine sulfoxide reductase MsrB.	0.400
EMR03008.1	msrB_3	ADICEAN_01857	ADICEAN_01414	Hypothetical protein.	Peptide methionine sulfoxide reductase MsrB.	0.400
EMR03800.1	EMR01013.1	ADICEAN_01041	ADICEAN_03862	Thiol:disulfide interchange protein precursor.	Hypothetical protein.	0.807
EMR03800.1	EMR03007.1	ADICEAN_01041	ADICEAN_01856	Thiol:disulfide interchange protein precursor.	Hypothetical protein.	0.807
EMR03800.1	EMR03008.1	ADICEAN_01041	ADICEAN_01857	Thiol:disulfide interchange protein precursor.	Hypothetical protein.	0.807

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.902

expected number of edges:

18

PPI enrichment p-value:

2.28e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044205

De novo UMP biosynthetic process

7 of 15

2.4

5.72

1.46e-12

GO:0006207

De novo pyrimidine nucleobase biosynthetic process

4 of 5

2.63

3.91

4.03e-08

GO:0022900

Electron transport chain

5 of 70

1.58

2.05

4.37e-06

GO:1901566

Organonitrogen compound biosynthetic process

8 of 498

0.93

0.95

1.20e-05

GO:0044281

Small molecule metabolic process

8 of 561

0.88

0.86

2.78e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016491

Oxidoreductase activity

7 of 243

1.19

1.25

4.81e-05

GO:0051536

Iron-sulfur cluster binding

6 of 187

1.23

1.22

0.00017

GO:0009055

Electron transfer activity

3 of 29

1.74

1.16

0.0043

GO:0030976

Thiamine pyrophosphate binding

2 of 9

2.07

0.93

0.0182

GO:0051537

2 iron, 2 sulfur cluster binding

2 of 17

1.8

0.75

0.0356

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1655

De novo UMP biosynthetic process

7 of 10

2.57

6.41

1.68e-13

CL:1657

De novo pyrimidine nucleobase biosynthetic process, and Uracil phosphoribosyltransferase activity

3 of 5

2.51

2.33

4.30e-05

CL:1147

Pyruvate:ferredoxin oxidoreductase core domain II, and Dicarboxylic acid catabolic process

2 of 5

2.33

1.14

0.0077

CL:1141

Citrate cycle (TCA cycle), and Alanine, aspartate and glutamate metabolism

3 of 34

1.67

1.1

0.0051

CL:1136

Mixed, incl. Generation of precursor metabolites and energy, and Pyruvate metabolism

4 of 118

1.26

0.87

0.0066

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00240

Pyrimidine metabolism

7 of 59

1.8

3.48

6.06e-10

map00250

Alanine, aspartate and glutamate metabolism

3 of 36

1.65

1.28

0.0017

map00020

Citrate cycle (TCA cycle)

2 of 18

1.77

0.89

0.0175

map00650

Butanoate metabolism

2 of 21

1.71

0.87

0.0186

map01100

Metabolic pathways

11 of 1639

0.55

0.49

4.85e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990204

Oxidoreductase complex

3 of 43

1.57

0.82

0.0208

GOCC:1902494

Catalytic complex

5 of 310

0.94

0.57

0.0221

GOCC:0005737

Cytoplasm

7 of 926

0.61

0.36

0.0442

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0665

Pyrimidine biosynthesis

5 of 11

2.39

4.1

7.15e-09

KW-0560

Oxidoreductase

5 of 129

1.32

1.28

0.00025

KW-0249

Electron transport

2 of 6

2.25

1.18

0.0062

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF17147

Pyruvate:ferredoxin oxidoreductase core domain II

2 of 3

2.55

0.89

0.0241

PF14691

Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster

2 of 3

2.55

0.89

0.0241

PF13450

NAD(P)-binding Rossmann-like domain

2 of 6

2.25

0.88

0.0241

PF01855

Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg

2 of 5

2.33

0.88

0.0241

PF01558

Pyruvate ferredoxin/flavodoxin oxidoreductase

2 of 5

2.33

0.88

0.0241

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR037112

Pyruvate-flavodoxin oxidoreductase, EKR domain superfamily

2 of 2

2.73

0.8

0.0357

IPR033412

Pyruvate:ferredoxin oxidoreductase, core domain II

2 of 3

2.55

0.8

0.0357

IPR028261

Dihydroprymidine dehydrogenase domain II

2 of 3

2.55

0.8

0.0357

IPR019456

Pyruvate-flavodoxin oxidoreductase, EKR domain

2 of 2

2.73

0.8

0.0357

IPR011895

Pyruvate-flavodoxin oxidoreductase

2 of 2

2.73

0.8

0.0357

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00890

Domain of unknown function

2 of 2

2.73

1.37

0.0032

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