STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
apf1Apicidin F synthase; Non-ribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of the cyclic tetrapeptide apicidin F (APF). The non-ribosomal peptide synthetase apf1 incorporates four different amino acids to produce apicidin F: L- phenylalanine, D-pipecolic acid (D-pip), N-methoxy-L-tryptophan and L- 2-aminooctanedioic acid. L-Phenylalanine is the only proteinogenic amino acid directly used by apf1. The 3 other apf1 substrates are non-proteinogenic and have to be modified by other enzymes of the cluster. Lysine is converted to delta-1-pyrroline-5-carbox [...] (5084 aa)    
Predicted Functional Partners:
FFUJ_12380
Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.
  
 0.893
FFUJ_08467
Tryptophan synthase.
  
 
 0.868
FFUJ_12522
Tryptophan synthase.
  
 
 0.868
FFUJ_00680
Histidine biosynthesis trifunctional protein.
   
  
 0.762
FFUJ_03752
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
   
  
 0.762
FFUJ_06276
Related to null pigmentation protein NpgA.
  
 0.715
apf8
Cytochrome P450 monooxygenase apf8; Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of the cyclic tetrapeptide apicidin F (APF). The non-ribosomal peptide synthetase apf1 incorporates four different amino acids to produce apicidin F: L- phenylalanine, D-pipecolic acid (D-pip), N-methoxy-L-tryptophan and L- 2-aminooctanedioic acid. L-Phenylalanine is the only proteinogenic amino acid directly used by apf1. The 3 other apf1 substrates are non-proteinogenic and have to be modified by other enzymes of the cluster. Lysine is converted to delta-1-pyrrol [...]
   
 0.675
apf7
Cytochrome P450 monooxygenase apf7; Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of the cyclic tetrapeptide apicidin F (APF). The non-ribosomal peptide synthetase apf1 incorporates four different amino acids to produce apicidin F: L- phenylalanine, D-pipecolic acid (D-pip), N-methoxy-L-tryptophan and L- 2-aminooctanedioic acid. L-Phenylalanine is the only proteinogenic amino acid directly used by apf1. The 3 other apf1 substrates are non-proteinogenic and have to be modified by other enzymes of the cluster. Lysine is converted to delta-1-pyrrol [...]
    
 0.646
FFUJ_04074
Related to glycerol transporter; Belongs to the membrane-bound acyltransferase family.
  
  
 0.640
PKS19
Polyketide synthase 19; Highly reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of fujikurins A-D, secondary metabolites playing a role during rice infection. The polyketide synthase PKS19 acts with the trans- enoyl reductase FFUJ_12240 and the polyketide transferase FFUJ_12241 to produce fujikurins, however, the biosynthesis pathway has not been identified yet.
   
 0.636
Your Current Organism:
Fusarium fujikuroi
NCBI taxonomy Id: 1279085
Other names: F. fujikuroi IMI 58289, Fusarium fujikuroi IMI 58289, Fusarium fujikuroi IMI58289, Gibberella fujikuroi IMI 58289
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