AXFE_02300 protein (Acidithrix ferrooxidans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

AXFE_02300

Pheromone autoinducer 2 transporter. (367 aa)

Predicted Functional Partners:

AXFE_02310

0.593

recG

0.532

purE

0.470

purB

0.450

pncC

0.447

guaA

0.437

ftsE

0.405

Your Current Organism:

Acidithrix ferrooxidans

NCBI taxonomy Id: 1280514
Other names: A. ferrooxidans, DSM 28176, JCM 19728, acid streamer bacterium Py-F3, strain PY-F3

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXFE_02300	AXFE_02310	AXFE_02300	AXFE_02310	Pheromone autoinducer 2 transporter.	Hypothetical protein.	0.593
AXFE_02300	ftsE	AXFE_02300	AXFE_34530	Pheromone autoinducer 2 transporter.	Cell division ATP-binding protein FtsE; Part of the ABC transporter FtsEX involved in cellular division.	0.405
AXFE_02300	guaA	AXFE_02300	AXFE_28990	Pheromone autoinducer 2 transporter.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.437
AXFE_02300	pncC	AXFE_02300	AXFE_00350	Pheromone autoinducer 2 transporter.	Nicotinamide-nucleotide amidohydrolase PncC; Belongs to the CinA family.	0.447
AXFE_02300	purB	AXFE_02300	AXFE_11780	Pheromone autoinducer 2 transporter.	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.450
AXFE_02300	purE	AXFE_02300	AXFE_30350	Pheromone autoinducer 2 transporter.	N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).	0.470
AXFE_02300	recG	AXFE_02300	AXFE_31960	Pheromone autoinducer 2 transporter.	ATP-dependent DNA helicase RecG.	0.532
AXFE_02310	AXFE_02300	AXFE_02310	AXFE_02300	Hypothetical protein.	Pheromone autoinducer 2 transporter.	0.593
ftsE	AXFE_02300	AXFE_34530	AXFE_02300	Cell division ATP-binding protein FtsE; Part of the ABC transporter FtsEX involved in cellular division.	Pheromone autoinducer 2 transporter.	0.405
ftsE	guaA	AXFE_34530	AXFE_28990	Cell division ATP-binding protein FtsE; Part of the ABC transporter FtsEX involved in cellular division.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.584
guaA	AXFE_02300	AXFE_28990	AXFE_02300	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Pheromone autoinducer 2 transporter.	0.437
guaA	ftsE	AXFE_28990	AXFE_34530	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Cell division ATP-binding protein FtsE; Part of the ABC transporter FtsEX involved in cellular division.	0.584
guaA	pncC	AXFE_28990	AXFE_00350	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Nicotinamide-nucleotide amidohydrolase PncC; Belongs to the CinA family.	0.540
guaA	purB	AXFE_28990	AXFE_11780	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.955
guaA	purE	AXFE_28990	AXFE_30350	GMP synthase; Catalyzes the synthesis of GMP from XMP.	N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).	0.813
pncC	AXFE_02300	AXFE_00350	AXFE_02300	Nicotinamide-nucleotide amidohydrolase PncC; Belongs to the CinA family.	Pheromone autoinducer 2 transporter.	0.447
pncC	guaA	AXFE_00350	AXFE_28990	Nicotinamide-nucleotide amidohydrolase PncC; Belongs to the CinA family.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.540
pncC	purB	AXFE_00350	AXFE_11780	Nicotinamide-nucleotide amidohydrolase PncC; Belongs to the CinA family.	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.656
purB	AXFE_02300	AXFE_11780	AXFE_02300	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	Pheromone autoinducer 2 transporter.	0.450
purB	guaA	AXFE_11780	AXFE_28990	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.955

page 1 of 2

Network Stats

number of nodes:

8

number of edges:

14

average node degree:

3.5

avg. local clustering coefficient:

0.875

expected number of edges:

7

PPI enrichment p-value:

0.016

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015628

Protein secretion by the type II secretion system

2 of 14

2.16

0.98

0.0224

GO:0071806

Protein transmembrane transport

3 of 49

1.79

0.93

0.0224

GO:0009306

Protein secretion

3 of 62

1.69

0.9

0.0224

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015627

Type II protein secretion system complex

2 of 9

2.35

1.27

0.0074

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:11743

Mostly uncharacterized, incl. Type II secretion system (T2SS), protein G, and Dioxygenase

5 of 29

2.24

3.75

9.74e-08

CL:11777

Mostly uncharacterized, incl. Cytosolic ribosome, and Peptidase family S41

3 of 12

2.4

2.21

0.00017

CL:11779

Mixed, incl. Tryptophan 2,3-dioxygenase, and Nuclease, putative, TT1808

2 of 5

2.6

1.27

0.0080

CL:11747

Mixed, incl. Type II secretion system (T2SS), protein G, and protein-(glutamine-N5) methyltransferase activity

2 of 6

2.52

1.25

0.0085

CL:10864

Type II protein secretion system complex, and NolW-like

2 of 7

2.46

1.23

0.0091

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ccx03070

Bacterial secretion system

4 of 48

1.92

2.47

1.28e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF08334

Type II secretion system (T2SS), protein G

3 of 5

2.78

2.69

3.37e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013545

Type II secretion system protein GspG, C-terminal

3 of 5

2.78

2.46

8.32e-05

IPR045584

Pilin-like

3 of 11

2.44

2.1

0.00027

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (18%) [HD]

Permalink

Network

Neighborhood

Databases

Cooccurrence

Textmining

Coexpression

Experiments

Fusion

© STRING Consortium 2024

Credits

Access

Info

About