STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
glnDBifunctional uridylyltransferase/uridylyl-removing enzyme; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. (773 aa)    
Predicted Functional Partners:
glnB1
Nitrogen regulatory protein P-II; Belongs to the P(II) protein family.
 
 
 0.985
glnB2
Nitrogen regulatory protein P-II; Belongs to the P(II) protein family.
 
 
 0.975
gltB2
Glutamate synthase [NADPH] large chain.
     
 0.796
nrgA1
Ammonium transporter NrgA.
     
 0.659
AXFE_14440
Hypothetical protein.
  
     0.643
glnII
Glutamine synthetase 2.
     
 0.531
glnA2
Glutamine synthetase.
     
 0.530
cobB
Cobyrinic acid A,C-diamide synthase.
   
    0.522
ipuC
Glutamate--isopropylamine ligase; Belongs to the glutamine synthetase family.
     
 0.521
nrgA2
Ammonium transporter NrgA.
     
 0.435
Your Current Organism:
Acidithrix ferrooxidans
NCBI taxonomy Id: 1280514
Other names: A. ferrooxidans, DSM 28176, JCM 19728, acid streamer bacterium Py-F3, strain PY-F3
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