node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AXFE_29000 | carB | AXFE_29000 | AXFE_23730 | Putative oxidoreductase/MSMEI_1564. | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. | 0.887 |
AXFE_29000 | glyA | AXFE_29000 | AXFE_18920 | Putative oxidoreductase/MSMEI_1564. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.826 |
AXFE_29000 | guaA | AXFE_29000 | AXFE_28990 | Putative oxidoreductase/MSMEI_1564. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.999 |
AXFE_29000 | hpt | AXFE_29000 | AXFE_10640 | Putative oxidoreductase/MSMEI_1564. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.834 |
AXFE_29000 | purA | AXFE_29000 | AXFE_11750 | Putative oxidoreductase/MSMEI_1564. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.976 |
AXFE_29000 | purB | AXFE_29000 | AXFE_11780 | Putative oxidoreductase/MSMEI_1564. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.877 |
AXFE_29000 | purC | AXFE_29000 | AXFE_11790 | Putative oxidoreductase/MSMEI_1564. | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. | 0.618 |
AXFE_29000 | purD | AXFE_29000 | AXFE_11760 | Putative oxidoreductase/MSMEI_1564. | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.560 |
AXFE_29000 | purF | AXFE_29000 | AXFE_11870 | Putative oxidoreductase/MSMEI_1564. | Amidophosphoribosyltransferase precursor; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.853 |
AXFE_29000 | purH | AXFE_29000 | AXFE_28860 | Putative oxidoreductase/MSMEI_1564. | Bifunctional purine biosynthesis protein PurH. | 0.911 |
carB | AXFE_29000 | AXFE_23730 | AXFE_29000 | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. | Putative oxidoreductase/MSMEI_1564. | 0.887 |
carB | glyA | AXFE_23730 | AXFE_18920 | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.557 |
carB | guaA | AXFE_23730 | AXFE_28990 | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.889 |
carB | purA | AXFE_23730 | AXFE_11750 | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.834 |
carB | purB | AXFE_23730 | AXFE_11780 | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.571 |
carB | purD | AXFE_23730 | AXFE_11760 | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.573 |
carB | purF | AXFE_23730 | AXFE_11870 | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. | Amidophosphoribosyltransferase precursor; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.943 |
carB | purH | AXFE_23730 | AXFE_28860 | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. | Bifunctional purine biosynthesis protein PurH. | 0.606 |
glyA | AXFE_29000 | AXFE_18920 | AXFE_29000 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative oxidoreductase/MSMEI_1564. | 0.826 |
glyA | carB | AXFE_18920 | AXFE_23730 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. | 0.557 |