STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HPO_08249Tat pathway signal sequence domain-containing protein; COG3211 Predicted phosphatase. (648 aa)    
Predicted Functional Partners:
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
   
 
  0.834
HPO_09418
COG1785 Alkaline phosphatase; Belongs to the alkaline phosphatase family.
  
  
 0.630
HPO_03829
COG3221 ABC-type phosphate/phosphonate transport system, periplasmic component.
   
    0.554
HPO_17295
COG0584 Glycerophosphoryl diester phosphodiesterase.
  
 
  0.544
HPO_08239
DnaJ domain-containing protein; COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain.
       0.527
HPO_08244
COG0443 Molecular chaperone; Belongs to the heat shock protein 70 family.
       0.527
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
    
  0.498
HPO_14831
dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
    
  0.424
Your Current Organism:
Hyphomonas polymorpha
NCBI taxonomy Id: 1280954
Other names: H. polymorpha PS728, Hyphomonas polymorpha PS728
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.