STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ESQ87623.1Leucine dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (355 aa)    
Predicted Functional Partners:
ESQ93120.1
Glutamate synthase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
  
 0.999
ESQ87622.1
MFS transporter; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
    
 0.985
ESQ89629.1
Pyruvate dehydrogenase subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
  
 
 0.974
ESQ87459.1
Pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.
  
 
 0.946
ilvE
Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 
 0.903
ESQ87235.1
Converts isocitrate to alpha ketoglutarate; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the isocitrate and isopropylmalate dehydrogenases family.
   
 0.900
cobB
NAD-dependent deacetylase; Modulates the activities of several enzymes which are inactive in their acetylated form; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the sirtuin family. Class III subfamily.
   
 0.891
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
   
 
 0.886
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
 
  0.846
pdhA
Pyruvate dehydrogenase E1 subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 
 0.843
Your Current Organism:
Asticcacaulis sp. AC460
NCBI taxonomy Id: 1282360
Other names: A. sp. AC460
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