STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
metXHomoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. (322 aa)    
Predicted Functional Partners:
metB_1
Bifunctional cystathionine gamma-lyase/gamma-synthase.
 
 0.987
dhoM
Homoserine dehydrogenase.
 
 
 0.973
azlC
Branched-chain amino acid permease.
     
 0.940
AKC77282.1
Bifunctional cystathionine gamma-lyase/gamma-synthase.
   
 0.913
dnaC
Replicative DNA helicase DnaB; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily.
     
 0.869
ilvA_1
Threonine dehydratase biosynthetic, IlvA_1; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
  
 
 0.835
glyA
Serine hydroxymethyl transferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
    
 0.834
rplI
50S ribosomal protein L9; Binds to the 23S rRNA.
     
 0.811
trpB
Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
     
 0.803
sdaAB
L-serine dehydratase, iron-sulfur-dependent subunit beta.
     
  0.800
Your Current Organism:
Staphylococcus haemolyticus
NCBI taxonomy Id: 1283
Other names: ATCC 29970, CCM 2737, CCUG 7323, CIP 81.56, DSM 20263, JCM 2416, LMG 13349, LMG:13349, NCTC 11042, NRRL B-14755, S. haemolyticus
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