node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
arlR_2 | walK | ShL2_01374 | ShL2_00018 | Response regulator receiver. | Multi-sensor signal transduction histidine kinase, WalK. | 0.837 |
fmtC | graR | ShL2_01426 | ShL2_02084 | Oxacillin resistance-related FmtC protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms. | Winged helix family two component transcriptional regulator. | 0.843 |
fmtC | vraS | ShL2_01426 | ShL2_00957 | Oxacillin resistance-related FmtC protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms. | Integral membrane sensor signal transduction histidine kinase. | 0.602 |
fmtC | walK | ShL2_01426 | ShL2_00018 | Oxacillin resistance-related FmtC protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms. | Multi-sensor signal transduction histidine kinase, WalK. | 0.826 |
fmtC | walR | ShL2_01426 | ShL2_00017 | Oxacillin resistance-related FmtC protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms. | Transcriptional regulator WalR. | 0.439 |
fmtC | yycH | ShL2_01426 | ShL2_00019 | Oxacillin resistance-related FmtC protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms. | Two-component regulator YycH. | 0.599 |
graR | fmtC | ShL2_02084 | ShL2_01426 | Winged helix family two component transcriptional regulator. | Oxacillin resistance-related FmtC protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms. | 0.843 |
graR | vraS | ShL2_02084 | ShL2_00957 | Winged helix family two component transcriptional regulator. | Integral membrane sensor signal transduction histidine kinase. | 0.642 |
graR | walK | ShL2_02084 | ShL2_00018 | Winged helix family two component transcriptional regulator. | Multi-sensor signal transduction histidine kinase, WalK. | 0.797 |
ompR | walK | ShL2_01117 | ShL2_00018 | Response regulator OmpR. | Multi-sensor signal transduction histidine kinase, WalK. | 0.853 |
srrA_2 | walK | ShL2_01309 | ShL2_00018 | Winged helix family two component transcriptional regulator. | Multi-sensor signal transduction histidine kinase, WalK. | 0.821 |
vraS | fmtC | ShL2_00957 | ShL2_01426 | Integral membrane sensor signal transduction histidine kinase. | Oxacillin resistance-related FmtC protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms. | 0.602 |
vraS | graR | ShL2_00957 | ShL2_02084 | Integral membrane sensor signal transduction histidine kinase. | Winged helix family two component transcriptional regulator. | 0.642 |
vraS | walK | ShL2_00957 | ShL2_00018 | Integral membrane sensor signal transduction histidine kinase. | Multi-sensor signal transduction histidine kinase, WalK. | 0.750 |
walK | arlR_2 | ShL2_00018 | ShL2_01374 | Multi-sensor signal transduction histidine kinase, WalK. | Response regulator receiver. | 0.837 |
walK | fmtC | ShL2_00018 | ShL2_01426 | Multi-sensor signal transduction histidine kinase, WalK. | Oxacillin resistance-related FmtC protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms. | 0.826 |
walK | graR | ShL2_00018 | ShL2_02084 | Multi-sensor signal transduction histidine kinase, WalK. | Winged helix family two component transcriptional regulator. | 0.797 |
walK | ompR | ShL2_00018 | ShL2_01117 | Multi-sensor signal transduction histidine kinase, WalK. | Response regulator OmpR. | 0.853 |
walK | srrA_2 | ShL2_00018 | ShL2_01309 | Multi-sensor signal transduction histidine kinase, WalK. | Winged helix family two component transcriptional regulator. | 0.821 |
walK | vraS | ShL2_00018 | ShL2_00957 | Multi-sensor signal transduction histidine kinase, WalK. | Integral membrane sensor signal transduction histidine kinase. | 0.750 |