STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
walKMulti-sensor signal transduction histidine kinase, WalK. (608 aa)    
Predicted Functional Partners:
walR
Transcriptional regulator WalR.
 0.999
yycH
Two-component regulator YycH.
  
  
 0.967
yycI
Regulatory protein YycI.
 
  
 0.967
yycJ
Metallo-beta-lactamase hydrolase.
  
  
 0.891
ompR
Response regulator OmpR.
 
 0.853
arlR_2
Response regulator receiver.
 
 0.837
fmtC
Oxacillin resistance-related FmtC protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.
     
 0.826
srrA_2
Winged helix family two component transcriptional regulator.
 
 0.821
graR
Winged helix family two component transcriptional regulator.
 
 0.797
vraS
Integral membrane sensor signal transduction histidine kinase.
 
    
 0.750
Your Current Organism:
Staphylococcus haemolyticus
NCBI taxonomy Id: 1283
Other names: ATCC 29970, CCM 2737, CCUG 7323, CIP 81.56, DSM 20263, JCM 2416, LMG 13349, LMG:13349, NCTC 11042, NRRL B-14755, S. haemolyticus
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