node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKC75010.1 | dinG | ShL2_00122 | ShL2_01340 | DNA mismatch repair ATPase. | DNA polymerase III, epsilon subunit/ATP-dependent helicase DinG; 3'-5' exonuclease. | 0.430 |
AKC75010.1 | dinP | ShL2_00122 | ShL2_00944 | DNA mismatch repair ATPase. | DNA-directed DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | 0.685 |
AKC75010.1 | dnaN | ShL2_00122 | ShL2_00002 | DNA mismatch repair ATPase. | DNA-directed DNA polymerase beta subunit, DnaN; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for [...] | 0.829 |
AKC75010.1 | mutL | ShL2_00122 | ShL2_01546 | DNA mismatch repair ATPase. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.993 |
AKC75010.1 | polA | ShL2_00122 | ShL2_01119 | DNA mismatch repair ATPase. | DNA-directed DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.776 |
AKC75010.1 | recA | ShL2_00122 | ShL2_01562 | DNA mismatch repair ATPase. | Recombination protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.453 |
AKC75809.1 | dinP | ShL2_00943 | ShL2_00944 | Hypothetical protein. | DNA-directed DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | 0.618 |
dinG | AKC75010.1 | ShL2_01340 | ShL2_00122 | DNA polymerase III, epsilon subunit/ATP-dependent helicase DinG; 3'-5' exonuclease. | DNA mismatch repair ATPase. | 0.430 |
dinG | dinP | ShL2_01340 | ShL2_00944 | DNA polymerase III, epsilon subunit/ATP-dependent helicase DinG; 3'-5' exonuclease. | DNA-directed DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | 0.610 |
dinG | dnaN | ShL2_01340 | ShL2_00002 | DNA polymerase III, epsilon subunit/ATP-dependent helicase DinG; 3'-5' exonuclease. | DNA-directed DNA polymerase beta subunit, DnaN; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for [...] | 0.973 |
dinG | lexA | ShL2_01340 | ShL2_01445 | DNA polymerase III, epsilon subunit/ATP-dependent helicase DinG; 3'-5' exonuclease. | DNA damage-inducible repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.645 |
dinG | mutL | ShL2_01340 | ShL2_01546 | DNA polymerase III, epsilon subunit/ATP-dependent helicase DinG; 3'-5' exonuclease. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.672 |
dinG | mutS | ShL2_01340 | ShL2_01547 | DNA polymerase III, epsilon subunit/ATP-dependent helicase DinG; 3'-5' exonuclease. | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. | 0.499 |
dinG | polA | ShL2_01340 | ShL2_01119 | DNA polymerase III, epsilon subunit/ATP-dependent helicase DinG; 3'-5' exonuclease. | DNA-directed DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.861 |
dinG | recA | ShL2_01340 | ShL2_01562 | DNA polymerase III, epsilon subunit/ATP-dependent helicase DinG; 3'-5' exonuclease. | Recombination protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.722 |
dinP | AKC75010.1 | ShL2_00944 | ShL2_00122 | DNA-directed DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | DNA mismatch repair ATPase. | 0.685 |
dinP | AKC75809.1 | ShL2_00944 | ShL2_00943 | DNA-directed DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | Hypothetical protein. | 0.618 |
dinP | dinG | ShL2_00944 | ShL2_01340 | DNA-directed DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | DNA polymerase III, epsilon subunit/ATP-dependent helicase DinG; 3'-5' exonuclease. | 0.610 |
dinP | dnaN | ShL2_00944 | ShL2_00002 | DNA-directed DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | DNA-directed DNA polymerase beta subunit, DnaN; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for [...] | 0.916 |
dinP | lexA | ShL2_00944 | ShL2_01445 | DNA-directed DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | DNA damage-inducible repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.908 |