STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
kgdOxoglutarate dehydrogenase (succinyl-transferring) E1; E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). (934 aa)    
Predicted Functional Partners:
odhB
Dihydrolipoamide succinyltransferase E2 component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
 0.999
pdhC
Pyruvate dehydrogenase complex dihydrolipoyllysine-residue acetyltransferase.
 0.982
bfmB_2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex.
 0.975
pdhD_2
Dihydrolipoamide dehydrogenase component of pyruvate dehydrogenase E3.
  
 0.972
pdhD_3
Dihydrolipoamide dehydrogenase component of pyruvate dehydrogenase E3.
  
 0.972
lpdA
Dihydrolipoamide dehydrogenase.
  
 0.972
pdhD_4
Dihydrolipoamide dehydrogenase component of pyruvate dehydrogenase E3.
  
 0.972
citC
Isocitrate dehydrogenase.
   
 
 0.965
sucC
succinate--CoA ligase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 0.959
sucD
succinate--CoA ligase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 
 0.957
Your Current Organism:
Staphylococcus haemolyticus
NCBI taxonomy Id: 1283
Other names: ATCC 29970, CCM 2737, CCUG 7323, CIP 81.56, DSM 20263, JCM 2416, LMG 13349, LMG:13349, NCTC 11042, NRRL B-14755, S. haemolyticus
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.