node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKC77076.1 | gmk | ShL2_02225 | ShL2_01637 | Deoxynucleoside kinase. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.918 |
apt | gmk | ShL2_01168 | ShL2_01637 | Adenine phosphoribosyl transferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.947 |
apt | guaA | ShL2_01168 | ShL2_02357 | Adenine phosphoribosyl transferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. | 0.980 |
apt | guaC | ShL2_01168 | ShL2_01447 | Adenine phosphoribosyl transferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.936 |
apt | hpt | ShL2_01168 | ShL2_02286 | Adenine phosphoribosyl transferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.934 |
apt | relA | ShL2_01168 | ShL2_01169 | Adenine phosphoribosyl transferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GTP pyrophosphokinase, (p)ppGpp synthetase I, RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.796 |
apt | xprT | ShL2_01168 | ShL2_02360 | Adenine phosphoribosyl transferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.926 |
gmk | AKC77076.1 | ShL2_01637 | ShL2_02225 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Deoxynucleoside kinase. | 0.918 |
gmk | apt | ShL2_01637 | ShL2_01168 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Adenine phosphoribosyl transferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.947 |
gmk | guaA | ShL2_01637 | ShL2_02357 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. | 0.967 |
gmk | guaC | ShL2_01637 | ShL2_01447 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.918 |
gmk | hpt | ShL2_01637 | ShL2_02286 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.926 |
gmk | ndk | ShL2_01637 | ShL2_01328 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Nucleoside diphosphate kinase superfamily protein; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.936 |
gmk | pykA | ShL2_01637 | ShL2_01112 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.946 |
gmk | relA | ShL2_01637 | ShL2_01169 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GTP pyrophosphokinase, (p)ppGpp synthetase I, RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.926 |
gmk | rpoZ | ShL2_01637 | ShL2_01636 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.995 |
gmk | xprT | ShL2_01637 | ShL2_02360 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.962 |
guaA | apt | ShL2_02357 | ShL2_01168 | Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. | Adenine phosphoribosyl transferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.980 |
guaA | gmk | ShL2_02357 | ShL2_01637 | Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.967 |
guaA | guaC | ShL2_02357 | ShL2_01447 | Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.999 |