Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AKC77286.1Cyclase enzyme. (247 aa)    
Predicted Functional Partners:
disA
Checkpoint controller nucleotide-binding protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria; Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
      
 0.849
AKC74903.1
Bifunctional signaling protein/50S ribosomal protein L9; Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP); Belongs to the GdpP/PdeA phosphodiesterase family.
      
 0.814
AKC75261.1
Glyoxalase/bleomycin resistance protein/dioxygenase.
      
 0.793
metH
Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase.
       0.714
AKC77282.1
Bifunctional cystathionine gamma-lyase/gamma-synthase.
       0.712
AKC77283.1
Bifunctional cystathionine gamma-lyase/gamma-synthase.
       0.712
metE
5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
       0.712
lrgB_2
Antiholin-like protein LrgB; Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like proteins CidA and/or CidB. The LrgAB and CidAB proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses; Belongs to the CidB/LrgB family. LrgB subfamily.
      
 0.579
AKC75279.1
Maltose O-acetyltransferase.
     
 0.531
purF
Amidophosphoribosyltransferase precursor; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
      
 0.401
Your Current Organism:
Staphylococcus haemolyticus
NCBI taxonomy Id: 1283
Other names: ATCC 29970, CCM 2737, CCUG 7323, CIP 81.56, DSM 20263, JCM 2416, LMG 13349, LMG:13349, NCTC 11042, NRRL B-14755, S. haemolyticus
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