node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FEN1 | S40285_00850 | A0A084QST8 | A0A084QJL0 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | AAA domain-containing protein. | 0.941 |
FEN1 | S40285_01432 | A0A084QST8 | A0A084QLB9 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. | 0.845 |
FEN1 | S40285_01558 | A0A084QST8 | A0A084QWA3 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 3'-5' exonuclease domain-containing protein. | 0.999 |
FEN1 | S40285_01629 | A0A084QST8 | A0A084QDU9 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Checkpoint protein; Belongs to the HUS1 family. | 0.910 |
FEN1 | S40285_01956 | A0A084QST8 | A0A084QIH9 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | AAA domain-containing protein. | 0.876 |
FEN1 | S40285_03290 | A0A084QST8 | A0A084QGU7 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | AAA domain-containing protein. | 0.861 |
FEN1 | S40285_03362 | A0A084QST8 | A0A084QQD3 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | AAA domain-containing protein. | 0.943 |
FEN1 | S40285_04581 | A0A084QST8 | A0A084QKU0 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation. | 0.896 |
FEN1 | S40285_05510 | A0A084QST8 | A0A084QBE9 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | AAA domain-containing protein. | 0.930 |
FEN1 | S40285_07561 | A0A084QST8 | A0A084Q8C2 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein. | 0.908 |
S40285_00850 | FEN1 | A0A084QJL0 | A0A084QST8 | AAA domain-containing protein. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.941 |
S40285_00850 | S40285_01432 | A0A084QJL0 | A0A084QLB9 | AAA domain-containing protein. | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. | 0.865 |
S40285_00850 | S40285_01558 | A0A084QJL0 | A0A084QWA3 | AAA domain-containing protein. | 3'-5' exonuclease domain-containing protein. | 0.990 |
S40285_00850 | S40285_01629 | A0A084QJL0 | A0A084QDU9 | AAA domain-containing protein. | Checkpoint protein; Belongs to the HUS1 family. | 0.984 |
S40285_00850 | S40285_01956 | A0A084QJL0 | A0A084QIH9 | AAA domain-containing protein. | AAA domain-containing protein. | 0.999 |
S40285_00850 | S40285_03290 | A0A084QJL0 | A0A084QGU7 | AAA domain-containing protein. | AAA domain-containing protein. | 0.999 |
S40285_00850 | S40285_03362 | A0A084QJL0 | A0A084QQD3 | AAA domain-containing protein. | AAA domain-containing protein. | 0.999 |
S40285_00850 | S40285_04581 | A0A084QJL0 | A0A084QKU0 | AAA domain-containing protein. | DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation. | 0.983 |
S40285_00850 | S40285_05510 | A0A084QJL0 | A0A084QBE9 | AAA domain-containing protein. | AAA domain-containing protein. | 0.999 |
S40285_00850 | S40285_07561 | A0A084QJL0 | A0A084Q8C2 | AAA domain-containing protein. | Uncharacterized protein. | 0.971 |