S40285_05969 protein (Stachybotrys chlorohalonata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

S40285_05969

AA_TRNA_LIGASE_II domain-containing protein. (767 aa)

Predicted Functional Partners:

S40285_02932

0.980

S40285_04878

0.980

S40285_02286

0.947

S40285_07055

0.947

S40285_06162

0.918

S40285_04305

0.918

S40285_08003

0.918

S40285_01972

0.915

S40285_04272

0.915

S40285_01476

0.908

Your Current Organism:

Stachybotrys chlorohalonata

NCBI taxonomy Id: 1283841
Other names: S. chlorohalonata IBT 40285, Stachybotrys chlorohalonata IBT 40285

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
S40285_01476	S40285_01972	A0A084QMM2	A0A084QII6	AA_TRNA_LIGASE_II domain-containing protein.	Uncharacterized protein.	0.984
S40285_01476	S40285_02286	A0A084QMM2	A0A084QFX7	AA_TRNA_LIGASE_II domain-containing protein.	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.995
S40285_01476	S40285_02932	A0A084QMM2	A0A084QK25	AA_TRNA_LIGASE_II domain-containing protein.	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.993
S40285_01476	S40285_04272	A0A084QMM2	A0A084QUB8	AA_TRNA_LIGASE_II domain-containing protein.	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.915
S40285_01476	S40285_04305	A0A084QMM2	A0A084QQ86	AA_TRNA_LIGASE_II domain-containing protein.	DALR_1 domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.918
S40285_01476	S40285_04878	A0A084QMM2	A0A084QP45	AA_TRNA_LIGASE_II domain-containing protein.	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.980
S40285_01476	S40285_05969	A0A084QMM2	A0A084QBI7	AA_TRNA_LIGASE_II domain-containing protein.	AA_TRNA_LIGASE_II domain-containing protein.	0.908
S40285_01476	S40285_06162	A0A084QMM2	A0A084QL38	AA_TRNA_LIGASE_II domain-containing protein.	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.918
S40285_01476	S40285_07055	A0A084QMM2	A0A084QX50	AA_TRNA_LIGASE_II domain-containing protein.	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.995
S40285_01476	S40285_08003	A0A084QMM2	A0A084QU87	AA_TRNA_LIGASE_II domain-containing protein.	DALR_1 domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.918
S40285_01972	S40285_01476	A0A084QII6	A0A084QMM2	Uncharacterized protein.	AA_TRNA_LIGASE_II domain-containing protein.	0.984
S40285_01972	S40285_02286	A0A084QII6	A0A084QFX7	Uncharacterized protein.	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.977
S40285_01972	S40285_02932	A0A084QII6	A0A084QK25	Uncharacterized protein.	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.995
S40285_01972	S40285_04272	A0A084QII6	A0A084QUB8	Uncharacterized protein.	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.852
S40285_01972	S40285_04305	A0A084QII6	A0A084QQ86	Uncharacterized protein.	DALR_1 domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.866
S40285_01972	S40285_04878	A0A084QII6	A0A084QP45	Uncharacterized protein.	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.948
S40285_01972	S40285_05969	A0A084QII6	A0A084QBI7	Uncharacterized protein.	AA_TRNA_LIGASE_II domain-containing protein.	0.915
S40285_01972	S40285_06162	A0A084QII6	A0A084QL38	Uncharacterized protein.	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.866
S40285_01972	S40285_07055	A0A084QII6	A0A084QX50	Uncharacterized protein.	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.976
S40285_01972	S40285_08003	A0A084QII6	A0A084QU87	Uncharacterized protein.	DALR_1 domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.866

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

38

average node degree:

6.91

avg. local clustering coefficient:

0.738

expected number of edges:

10

PPI enrichment p-value:

3.59e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0010499

Proteasomal ubiquitin-independent protein catabolic process

10 of 23

2.87

11.86

3.39e-24

GO:0010498

Proteasomal protein catabolic process

11 of 274

1.83

5.16

2.04e-17

GO:0043161

Proteasome-mediated ubiquitin-dependent protein catabolic process

10 of 266

1.8

4.58

6.01e-15

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004298

Threonine-type endopeptidase activity

3 of 10

2.71

2.18

0.00010

GO:0061133

Endopeptidase activator activity

2 of 7

2.68

1.13

0.0090

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005839

Proteasome core complex

11 of 23

2.91

13.99

1.26e-28

GO:0019774

Proteasome core complex, beta-subunit complex

7 of 13

2.96

8.68

3.39e-17

GO:0034515

Proteasome storage granule

5 of 24

2.55

4.84

3.73e-10

GO:0019773

Proteasome core complex, alpha-subunit complex

4 of 10

2.83

4.36

7.46e-09

GO:0005634

Nucleus

11 of 4202

0.65

0.6

7.34e-06

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2901

Proteasome complex

11 of 56

2.52

10.74

1.76e-24

CL:2902

Proteasome complex

7 of 29

2.61

7.19

4.35e-15

CL:2988

Proteasome subunit

4 of 6

3.05

4.63

3.13e-09

CL:2940

Proteasome B-type subunit, and Proteasome subunit alpha6

4 of 7

2.99

4.53

4.59e-09

CL:2907

Proteasome-activating activity, and Proteasome core complex, alpha-subunit complex

2 of 11

2.49

1.29

0.0043

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03050

Proteasome

11 of 74

2.4

10.15

1.44e-24

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1236978

Cross-presentation of soluble exogenous antigens (endosomes)

11 of 72

2.41

9.99

6.99e-24

MAP-1236975

Antigen processing-Cross presentation

11 of 74

2.4

9.93

6.99e-24

MAP-5689880

Ub-specific processing proteases

11 of 145

2.11

7.5

3.36e-21

MAP-5688426

Deubiquitination

11 of 212

1.94

6.17

1.43e-19

MAP-983169

Class I MHC mediated antigen processing & presentation

11 of 323

1.76

4.82

1.06e-17

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005839

Proteasome core complex

9 of 21

2.86

10.64

1.38e-21

GOCC:0019774

Proteasome core complex, beta-subunit complex

7 of 13

2.96

8.43

1.08e-16

GOCC:0019773

Proteasome core complex, alpha-subunit complex

2 of 8

2.63

1.44

0.0023

GOCC:0032991

Protein-containing complex

11 of 4391

0.63

0.56

2.37e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0888

Threonine protease

10 of 20

2.93

12.8

6.83e-26

KW-0647

Proteasome

8 of 28

2.68

8.82

1.98e-18

KW-0963

Cytoplasm

10 of 269

1.8

4.77

3.75e-16

KW-0539

Nucleus

10 of 568

1.47

2.92

4.69e-13

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00227

Proteasome subunit

11 of 24

2.89

13.66

5.00e-28

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001353

Proteasome, subunit alpha/beta

11 of 24

2.89

13.47

1.34e-27

IPR029055

Nucleophile aminohydrolases, N-terminal

11 of 49

2.58

11.19

5.51e-25

IPR023333

Proteasome B-type subunit

7 of 13

2.96

8.14

4.14e-16

IPR016050

Proteasome beta-type subunit, conserved site

6 of 12

2.93

6.68

2.76e-13

IPR023332

Proteasome alpha-type subunit

4 of 11

2.79

3.7

1.34e-07

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00948

Proteasome subunit A N-terminal signature Add an annotation

4 of 11

2.79

3.92

5.08e-08

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