S40285_08891 protein (Stachybotrys chlorohalonata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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Coexpression

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[Homology]

Score

S40285_08891

Uncharacterized protein. (2331 aa)

Predicted Functional Partners:

S40285_00790

0.774

S40285_08510

0.725

S40285_03570

0.714

S40285_00186

0.683

S40285_05554

0.660

S40285_01435

0.645

S40285_01440

0.609

S40285_06964

0.609

S40285_10474

0.602

S40285_06570

0.601

Your Current Organism:

Stachybotrys chlorohalonata

NCBI taxonomy Id: 1283841
Other names: S. chlorohalonata IBT 40285, Stachybotrys chlorohalonata IBT 40285

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
S40285_00186	S40285_00790	A0A084QTU4	A0A084QJP4	Peptidase C50 domain-containing protein.	Protein kinase domain-containing protein.	0.990
S40285_00186	S40285_01440	A0A084QTU4	A0A084QL99	Peptidase C50 domain-containing protein.	Metallophos domain-containing protein.	0.760
S40285_00186	S40285_06964	A0A084QTU4	A0A084QV35	Peptidase C50 domain-containing protein.	Serine/threonine-protein phosphatase.	0.802
S40285_00186	S40285_08510	A0A084QTU4	A0A084Q7Q6	Peptidase C50 domain-containing protein.	Protein phosphatase PP2A regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	0.954
S40285_00186	S40285_08891	A0A084QTU4	A0A084QCZ8	Peptidase C50 domain-containing protein.	Uncharacterized protein.	0.683
S40285_00790	S40285_00186	A0A084QJP4	A0A084QTU4	Protein kinase domain-containing protein.	Peptidase C50 domain-containing protein.	0.990
S40285_00790	S40285_01435	A0A084QJP4	A0A084QLF8	Protein kinase domain-containing protein.	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.627
S40285_00790	S40285_01440	A0A084QJP4	A0A084QL99	Protein kinase domain-containing protein.	Metallophos domain-containing protein.	0.929
S40285_00790	S40285_05554	A0A084QJP4	A0A084QFH5	Protein kinase domain-containing protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.850
S40285_00790	S40285_06964	A0A084QJP4	A0A084QV35	Protein kinase domain-containing protein.	Serine/threonine-protein phosphatase.	0.967
S40285_00790	S40285_08510	A0A084QJP4	A0A084Q7Q6	Protein kinase domain-containing protein.	Protein phosphatase PP2A regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	0.956
S40285_00790	S40285_08891	A0A084QJP4	A0A084QCZ8	Protein kinase domain-containing protein.	Uncharacterized protein.	0.774
S40285_01435	S40285_00790	A0A084QLF8	A0A084QJP4	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Protein kinase domain-containing protein.	0.627
S40285_01435	S40285_08891	A0A084QLF8	A0A084QCZ8	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Uncharacterized protein.	0.645
S40285_01440	S40285_00186	A0A084QL99	A0A084QTU4	Metallophos domain-containing protein.	Peptidase C50 domain-containing protein.	0.760
S40285_01440	S40285_00790	A0A084QL99	A0A084QJP4	Metallophos domain-containing protein.	Protein kinase domain-containing protein.	0.929
S40285_01440	S40285_08510	A0A084QL99	A0A084Q7Q6	Metallophos domain-containing protein.	Protein phosphatase PP2A regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	0.982
S40285_01440	S40285_08891	A0A084QL99	A0A084QCZ8	Metallophos domain-containing protein.	Uncharacterized protein.	0.609
S40285_03570	S40285_05554	A0A084QBQ6	A0A084QFH5	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.561
S40285_03570	S40285_08891	A0A084QBQ6	A0A084QCZ8	Uncharacterized protein.	Uncharacterized protein.	0.714

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

13

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0034427

Nuclear-transcribed mRNA catabolic process, exonucleolytic, 3-5

9 of 14

3.23

12.46

4.64e-24

GO:0034475

U4 snRNA 3-end processing

7 of 9

3.31

9.67

1.52e-18

GO:0071027

Nuclear RNA surveillance

7 of 14

3.12

9.16

7.72e-18

GO:0043628

Small regulatory ncRNA 3-end processing

7 of 20

2.97

8.68

3.53e-17

GO:0016075

rRNA catabolic process

7 of 20

2.97

8.68

3.53e-17

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003723

RNA binding

9 of 1635

1.16

1.45

5.78e-07

GO:0003676

Nucleic acid binding

10 of 4082

0.81

0.77

2.92e-05

GO:0005488

Binding

11 of 12011

0.38

0.28

0.0243

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000178

Exosome (RNase complex)

8 of 22

2.98

10.06

6.13e-20

GO:0000177

Cytoplasmic exosome (RNase complex)

7 of 14

3.12

9.38

2.95e-18

GO:0000176

Nuclear exosome (RNase complex)

7 of 17

3.04

9.12

6.58e-18

GO:0031981

Nuclear lumen

8 of 785

1.43

2.28

7.30e-09

GO:0055087

Ski complex

2 of 4

3.12

2.15

0.00013

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2719

Nuclear RNA surveillance

9 of 15

3.2

12.32

7.57e-24

CL:2723

U4 snRNA 3-end processing

8 of 10

3.32

11.4

8.18e-22

CL:2728

Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA

5 of 5

3.42

6.81

4.12e-13

CL:14777

Regulation of wax biosynthetic process

2 of 5

3.02

1.56

0.0015

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

dct03018

RNA degradation

10 of 86

2.49

9.89

1.37e-22

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-429958

mRNA decay by 3 to 5 exoribonuclease

10 of 24

3.04

13.47

9.97e-27

MAP-450385

Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA

8 of 12

3.25

11.37

6.73e-22

MAP-450513

Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA

8 of 13

3.21

11.32

7.24e-22

MAP-429914

Deadenylation-dependent mRNA decay

10 of 99

2.43

9.35

8.09e-22

MAP-450531

Regulation of mRNA stability by proteins that bind AU-rich elements

8 of 85

2.4

7.25

2.16e-16

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1905354

Exoribonuclease complex

9 of 31

2.88

10.91

4.60e-22

GOCC:0000178

Exosome (RNase complex)

8 of 22

2.98

10.12

4.76e-20

GOCC:0055087

Ski complex

2 of 6

2.94

1.68

0.00090

GOCC:0032991

Protein-containing complex

11 of 3589

0.91

1.04

3.25e-08

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01138

3 exoribonuclease family, domain 1

4 of 8

3.12

4.38

9.72e-09

PF15985

KH domain

3 of 3

3.42

3.4

7.14e-07

PF03725

3 exoribonuclease family, domain 2

3 of 6

3.12

3.14

2.00e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036345

Exoribonuclease, PH domain 2 superfamily

4 of 8

3.12

4.13

2.87e-08

IPR027408

PNPase/RNase PH domain superfamily

4 of 8

3.12

4.13

2.87e-08

IPR001247

Exoribonuclease, phosphorolytic domain 1

4 of 8

3.12

4.13

2.87e-08

IPR026699

Exosome complex RNA-binding protein 1/RRP40/RRP4

3 of 3

3.42

3.31

1.05e-06

IPR015847

Exoribonuclease, phosphorolytic domain 2

3 of 6

3.12

3.0

3.54e-06

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00316

Ribosomal protein S1-like RNA-binding domain

4 of 20

2.72

3.88

5.51e-08

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