S40285_08814 protein (Stachybotrys chlorohalonata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

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[Homology]

Score

S40285_08814

Uncharacterized protein. (242 aa)

Predicted Functional Partners:

S40285_05043

0.992

S40285_06143

0.800

S40285_00645

0.790

S40285_00172

0.769

S40285_02624

0.761

S40285_01540

0.756

S40285_07310

0.736

S40285_01305

0.733

S40285_00721

0.728

S40285_03616

0.725

Your Current Organism:

Stachybotrys chlorohalonata

NCBI taxonomy Id: 1283841
Other names: S. chlorohalonata IBT 40285, Stachybotrys chlorohalonata IBT 40285

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
S40285_00172	S40285_00645	A0A084QTV8	A0A084R2R2	Uncharacterized protein.	Uncharacterized protein.	0.827
S40285_00172	S40285_00721	A0A084QTV8	A0A084QRB6	Uncharacterized protein.	Uncharacterized protein.	0.990
S40285_00172	S40285_01305	A0A084QTV8	A0A084QQV2	Uncharacterized protein.	Uncharacterized protein.	0.991
S40285_00172	S40285_01540	A0A084QTV8	A0A084QMM0	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein; Belongs to the WD repeat SEC13 family.	0.984
S40285_00172	S40285_02624	A0A084QTV8	A0A084QXJ4	Uncharacterized protein.	Uncharacterized protein.	0.999
S40285_00172	S40285_03616	A0A084QTV8	A0A084QBT3	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.893
S40285_00172	S40285_05043	A0A084QTV8	A0A084QFK1	Uncharacterized protein.	Uncharacterized protein.	0.999
S40285_00172	S40285_06143	A0A084QTV8	A0A084QL33	Uncharacterized protein.	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC).	0.992
S40285_00172	S40285_07310	A0A084QTV8	A0A084QRK1	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein; Belongs to the WD repeat SEC13 family.	0.983
S40285_00172	S40285_08814	A0A084QTV8	A0A084QD23	Uncharacterized protein.	Uncharacterized protein.	0.769
S40285_00645	S40285_00172	A0A084R2R2	A0A084QTV8	Uncharacterized protein.	Uncharacterized protein.	0.827
S40285_00645	S40285_00721	A0A084R2R2	A0A084QRB6	Uncharacterized protein.	Uncharacterized protein.	0.979
S40285_00645	S40285_01305	A0A084R2R2	A0A084QQV2	Uncharacterized protein.	Uncharacterized protein.	0.879
S40285_00645	S40285_01540	A0A084R2R2	A0A084QMM0	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein; Belongs to the WD repeat SEC13 family.	0.893
S40285_00645	S40285_02624	A0A084R2R2	A0A084QXJ4	Uncharacterized protein.	Uncharacterized protein.	0.867
S40285_00645	S40285_03616	A0A084R2R2	A0A084QBT3	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.986
S40285_00645	S40285_05043	A0A084R2R2	A0A084QFK1	Uncharacterized protein.	Uncharacterized protein.	0.999
S40285_00645	S40285_06143	A0A084R2R2	A0A084QL33	Uncharacterized protein.	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC).	0.971
S40285_00645	S40285_07310	A0A084R2R2	A0A084QRK1	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein; Belongs to the WD repeat SEC13 family.	0.666
S40285_00645	S40285_08814	A0A084R2R2	A0A084QD23	Uncharacterized protein.	Uncharacterized protein.	0.790

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

52

average node degree:

9.45

avg. local clustering coefficient:

0.953

expected number of edges:

26

PPI enrichment p-value:

3.4e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0050794

Regulation of cellular process

8 of 416

0.89

0.74

0.0010

GO:0000160

Phosphorelay signal transduction system

4 of 91

1.25

0.74

0.0178

GO:0016310

Phosphorylation

4 of 139

1.07

0.56

0.0384

GO:0006355

Regulation of transcription, DNA-templated

5 of 260

0.89

0.49

0.0384

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000155

Phosphorelay sensor kinase activity

6 of 55

1.64

2.34

8.11e-07

GO:0016301

Kinase activity

7 of 142

1.3

1.67

1.24e-06

GO:0016772

Transferase activity, transferring phosphorus-containing groups

9 of 230

1.2

1.59

1.14e-07

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3332

EAL domain, and Domain present in phytochromes and cGMP-specific phosphodiesterases.

6 of 16

2.18

4.37

3.73e-10

CL:3334

EAL domain, and PAS fold-3

5 of 11

2.26

3.88

1.18e-08

CL:3338

Mixed, incl. PAS fold-3, and HPT domain superfamily

4 of 5

2.51

3.53

1.72e-07

CL:3319

Phosphorelay signal transduction system, and Nucleotide cyclase

9 of 81

1.65

3.36

1.88e-11

CL:3437

His Kinase A (phosphoacceptor) domain, and OmpR/PhoB-type DNA-binding domain

3 of 13

1.97

1.7

0.00039

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

10 of 305

1.12

1.53

3.49e-09

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

4 of 51

1.5

1.33

0.00069

KW-0418

Kinase

5 of 102

1.3

1.17

0.00065

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000700

PAS-associated, C-terminal

4 of 17

1.98

2.2

2.79e-05

IPR035965

PAS domain superfamily

5 of 31

1.81

2.13

1.91e-05

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

5 of 35

1.76

2.08

1.91e-05

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

5 of 36

1.75

2.07

1.91e-05

IPR004358

Signal transduction histidine kinase-related protein, C-terminal

5 of 39

1.72

2.03

1.91e-05

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00091

PAS domain

5 of 27

1.87

2.68

8.28e-07

SM00388

His Kinase A (phosphoacceptor) domain

5 of 35

1.76

2.46

1.34e-06

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

4 of 19

1.93

2.42

6.10e-06

SM00387

Histidine kinase-like ATPases

5 of 53

1.58

2.01

6.10e-06

SM00448

cheY-homologous receiver domain

4 of 40

1.61

1.74

6.97e-05

(more ...)

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