S40285_01089 protein (Stachybotrys chlorohalonata)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

S40285_01089

Uncharacterized protein. (543 aa)

Predicted Functional Partners:

S40285_02648

0.963

S40285_06379

0.894

S40285_07845

0.753

S40285_07846

0.753

S40285_05826

0.750

S40285_08889

0.735

S40285_04590

0.735

S40285_05126

0.691

S40285_02547

0.691

S40285_00348

0.685

Your Current Organism:

Stachybotrys chlorohalonata

NCBI taxonomy Id: 1283841
Other names: S. chlorohalonata IBT 40285, Stachybotrys chlorohalonata IBT 40285

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
S40285_00348	S40285_01089	A0A084QHM7	A0A084QK92	DNA ligase.	Uncharacterized protein.	0.685
S40285_00348	S40285_02547	A0A084QHM7	A0A084QVT3	DNA ligase.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.753
S40285_00348	S40285_04590	A0A084QHM7	A0A084QKS0	DNA ligase.	DNA ligase.	0.632
S40285_00348	S40285_05126	A0A084QHM7	A0A084QSS9	DNA ligase.	HRDC domain-containing protein.	0.753
S40285_00348	S40285_05826	A0A084QHM7	A0A084QES8	DNA ligase.	SAP domain-containing protein.	0.887
S40285_00348	S40285_07845	A0A084QHM7	A0A084QFD0	DNA ligase.	Ku domain-containing protein.	0.857
S40285_00348	S40285_07846	A0A084QHM7	A0A084QFD1	DNA ligase.	VWFA domain-containing protein.	0.857
S40285_00348	S40285_08889	A0A084QHM7	A0A084Q992	DNA ligase.	DNA_LIGASE_A3 domain-containing protein.	0.629
S40285_01089	S40285_00348	A0A084QK92	A0A084QHM7	Uncharacterized protein.	DNA ligase.	0.685
S40285_01089	S40285_02547	A0A084QK92	A0A084QVT3	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.691
S40285_01089	S40285_02648	A0A084QK92	A0A084QXM2	Uncharacterized protein.	Uncharacterized protein.	0.963
S40285_01089	S40285_04590	A0A084QK92	A0A084QKS0	Uncharacterized protein.	DNA ligase.	0.735
S40285_01089	S40285_05126	A0A084QK92	A0A084QSS9	Uncharacterized protein.	HRDC domain-containing protein.	0.691
S40285_01089	S40285_05826	A0A084QK92	A0A084QES8	Uncharacterized protein.	SAP domain-containing protein.	0.750
S40285_01089	S40285_06379	A0A084QK92	A0A084QEE9	Uncharacterized protein.	Uncharacterized protein.	0.894
S40285_01089	S40285_07845	A0A084QK92	A0A084QFD0	Uncharacterized protein.	Ku domain-containing protein.	0.753
S40285_01089	S40285_07846	A0A084QK92	A0A084QFD1	Uncharacterized protein.	VWFA domain-containing protein.	0.753
S40285_01089	S40285_08889	A0A084QK92	A0A084Q992	Uncharacterized protein.	DNA_LIGASE_A3 domain-containing protein.	0.735
S40285_02547	S40285_00348	A0A084QVT3	A0A084QHM7	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	DNA ligase.	0.753
S40285_02547	S40285_01089	A0A084QVT3	A0A084QK92	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.691

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

41

average node degree:

7.45

avg. local clustering coefficient:

0.751

expected number of edges:

12

PPI enrichment p-value:

1.48e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006560

Proline metabolic process

6 of 13

2.71

5.87

5.21e-12

GO:0009064

Glutamine family amino acid metabolic process

8 of 71

2.09

5.04

1.35e-12

GO:0010133

Proline catabolic process to glutamate

4 of 4

3.04

4.16

2.35e-08

GO:0006536

Glutamate metabolic process

5 of 30

2.26

3.64

4.15e-08

GO:0009084

Glutamine family amino acid biosynthetic process

4 of 22

2.3

2.87

2.48e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004657

Proline dehydrogenase activity

2 of 2

3.04

1.19

0.0073

GO:0003842

1-pyrroline-5-carboxylate dehydrogenase activity

2 of 2

3.04

1.19

0.0073

GO:0016620

Oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

3 of 59

1.75

0.98

0.0110

GO:0003824

Catalytic activity

11 of 5229

0.36

0.27

0.0322

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005739

Mitochondrion

7 of 1098

0.85

0.57

0.0106

GO:0005737

Cytoplasm

11 of 5177

0.37

0.26

0.0383

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:13004

Glutamate and glutamine metabolism, and Proline catabolism

9 of 16

2.79

10.23

5.11e-21

CL:13006

Glutamate biosynthetic process, and Proline metabolic process

8 of 11

2.9

9.59

3.27e-19

CL:12928

Mixed, incl. Glutamine family amino acid metabolic process, and Glutamate and glutamine metabolism

11 of 74

2.21

8.15

2.20e-21

CL:13008

Oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor, and Glutamine synthetase, catalytic domain

4 of 6

2.86

4.2

1.62e-08

CL:13061

Pyrroline-5-carboxylate reductase, and Proline metabolism

2 of 5

2.64

1.38

0.0030

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00250

Alanine, aspartate and glutamate metabolism

6 of 74

1.95

3.56

4.75e-09

map00330

Arginine and proline metabolism

6 of 142

1.67

2.61

1.02e-07

map00910

Nitrogen metabolism

4 of 65

1.83

2.22

1.19e-05

map00332

Carbapenem biosynthesis

2 of 3

2.86

2.08

0.00016

map00220

Arginine biosynthesis

3 of 33

2.0

1.97

0.00010

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-70688

Proline catabolism

4 of 4

3.04

4.37

9.73e-09

MAP-8964539

Glutamate and glutamine metabolism

5 of 23

2.38

4.03

9.73e-09

MAP-389661

Glyoxylate metabolism and glycine degradation

4 of 53

1.92

2.12

3.33e-05

MAP-71291

Metabolism of amino acids and derivatives

9 of 459

1.33

2.02

8.62e-09

MAP-112315

Transmission across Chemical Synapses

3 of 74

1.65

1.06

0.0061

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005739

Mitochondrion

6 of 857

0.89

0.48

0.0437

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0642

Proline metabolism

3 of 3

3.04

3.06

2.72e-06

KW-0560

Oxidoreductase

4 of 350

1.1

0.63

0.0246

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00171

Aldehyde dehydrogenase family

3 of 44

1.87

1.04

0.0094

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036651

Glutamine synthetase, N-terminal domain superfamily

3 of 3

3.04

2.47

3.26e-05

IPR008146

Glutamine synthetase, catalytic domain

3 of 3

3.04

2.47

3.26e-05

IPR014746

Glutamine synthetase/guanido kinase, catalytic domain

3 of 6

2.74

2.36

4.56e-05

IPR005931

Delta-1-pyrroline-5-carboxylate dehydrogenase

2 of 2

3.04

1.37

0.0033

IPR016163

Aldehyde dehydrogenase, C-terminal

3 of 46

1.86

1.13

0.0059

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01230

Glutamine synthetase, catalytic domain

3 of 3

3.04

2.99

3.58e-06

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