S40285_03721 protein (Stachybotrys chlorohalonata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

S40285_03721

Uncharacterized protein. (817 aa)

Predicted Functional Partners:

S40285_01558

0.993

S40285_02771

0.990

S40285_05722

0.988

S40285_04581

0.983

S40285_01432

0.981

S40285_05688

0.973

S40285_04814

0.959

S40285_08353

0.945

S40285_01359

0.934

S40285_04337

0.930

Your Current Organism:

Stachybotrys chlorohalonata

NCBI taxonomy Id: 1283841
Other names: S. chlorohalonata IBT 40285, Stachybotrys chlorohalonata IBT 40285

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
S40285_01359	S40285_03721	A0A084QLI4	A0A084QPX3	PCI domain-containing protein.	Uncharacterized protein.	0.934
S40285_01359	S40285_05722	A0A084QLI4	A0A084QJ40	PCI domain-containing protein.	Uncharacterized protein.	0.607
S40285_01359	S40285_08353	A0A084QLI4	A0A084Q7N9	PCI domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.405
S40285_01432	S40285_01558	A0A084QLB9	A0A084QWA3	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	3'-5' exonuclease domain-containing protein.	0.999
S40285_01432	S40285_02771	A0A084QLB9	A0A084QAJ0	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	BRCT domain-containing protein.	0.988
S40285_01432	S40285_03721	A0A084QLB9	A0A084QPX3	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.981
S40285_01432	S40285_04337	A0A084QLB9	A0A084QNP4	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	BRCT domain-containing protein.	0.949
S40285_01432	S40285_04581	A0A084QLB9	A0A084QKU0	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation.	0.936
S40285_01432	S40285_04814	A0A084QLB9	A0A084QNZ7	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	DNA helicase; Belongs to the MCM family.	0.634
S40285_01432	S40285_05722	A0A084QLB9	A0A084QJ40	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.866
S40285_01432	S40285_08353	A0A084QLB9	A0A084Q7N9	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	DNA helicase; Belongs to the MCM family.	0.704
S40285_01558	S40285_01432	A0A084QWA3	A0A084QLB9	3'-5' exonuclease domain-containing protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.999
S40285_01558	S40285_02771	A0A084QWA3	A0A084QAJ0	3'-5' exonuclease domain-containing protein.	BRCT domain-containing protein.	0.883
S40285_01558	S40285_03721	A0A084QWA3	A0A084QPX3	3'-5' exonuclease domain-containing protein.	Uncharacterized protein.	0.993
S40285_01558	S40285_04337	A0A084QWA3	A0A084QNP4	3'-5' exonuclease domain-containing protein.	BRCT domain-containing protein.	0.996
S40285_01558	S40285_04581	A0A084QWA3	A0A084QKU0	3'-5' exonuclease domain-containing protein.	DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation.	0.993
S40285_01558	S40285_04814	A0A084QWA3	A0A084QNZ7	3'-5' exonuclease domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.794
S40285_01558	S40285_05722	A0A084QWA3	A0A084QJ40	3'-5' exonuclease domain-containing protein.	Uncharacterized protein.	0.736
S40285_01558	S40285_08353	A0A084QWA3	A0A084Q7N9	3'-5' exonuclease domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.547
S40285_02771	S40285_01432	A0A084QAJ0	A0A084QLB9	BRCT domain-containing protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.988

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

28

average node degree:

5.09

avg. local clustering coefficient:

0.836

expected number of edges:

30

PPI enrichment p-value:

0.64

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0001678

Cellular glucose homeostasis

6 of 14

2.86

6.28

1.41e-12

GO:0006096

Glycolytic process

6 of 41

2.39

5.01

6.48e-11

GO:0019318

Hexose metabolic process

6 of 85

2.08

3.97

1.41e-09

GO:0006006

Glucose metabolic process

4 of 46

2.17

2.84

1.85e-06

GO:0042128

Nitrate assimilation

3 of 17

2.47

2.52

1.80e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008865

Fructokinase activity

6 of 8

3.1

7.15

5.67e-14

GO:0005536

Glucose binding

6 of 8

3.1

7.15

5.67e-14

GO:0004340

Glucokinase activity

6 of 8

3.1

7.15

5.67e-14

GO:0050464

Nitrate reductase (NADPH) activity

3 of 4

3.1

3.19

1.58e-06

GO:0043546

Molybdopterin cofactor binding

3 of 10

2.71

2.74

8.61e-06

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005739

Mitochondrion

7 of 1638

0.86

0.58

0.0102

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:21208

Nitrate reductase (NADPH) activity

3 of 5

3.01

2.77

9.06e-06

CL:22918

Mixed, incl. Hexokinase, and Transaldolase type 1

3 of 7

2.86

2.64

1.46e-05

CL:22838

Mixed, incl. Pentose phosphate pathway, and Glycolysis

6 of 159

1.8

2.63

6.25e-07

CL:23117

Mixed, incl. N-acetylglucosamine catabolic process, and UDP-N-acetylglucosamine metabolic process

3 of 17

2.47

2.19

7.87e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00052

Galactose metabolism

6 of 90

2.05

3.96

1.14e-09

map00051

Fructose and mannose metabolism

6 of 122

1.92

3.55

3.30e-09

map00010

Glycolysis / Gluconeogenesis

6 of 157

1.81

3.18

9.54e-09

map00520

Amino sugar and nucleotide sugar metabolism

6 of 211

1.68

2.74

4.03e-08

map00500

Starch and sucrose metabolism

6 of 225

1.65

2.67

4.69e-08

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-170822

Regulation of Glucokinase by Glucokinase Regulatory Protein

6 of 7

3.16

7.5

1.38e-14

MAP-70171

Glycolysis

6 of 44

2.36

4.97

6.32e-11

MAP-70326

Glucose metabolism

6 of 188

1.73

2.67

1.76e-07

MAP-71387

Metabolism of carbohydrates

6 of 399

1.41

1.69

1.08e-05

MAP-6798695

Neutrophil degranulation

6 of 559

1.26

1.33

6.20e-05

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0324

Glycolysis

6 of 23

2.64

6.14

1.07e-12

KW-0418

Kinase

6 of 156

1.81

3.07

2.50e-08

KW-0534

Nitrate assimilation

2 of 6

2.75

1.85

0.00042

KW-0500

Molybdenum

2 of 6

2.75

1.85

0.00042

KW-0067

ATP-binding

6 of 549

1.27

1.41

2.63e-05

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03727

Hexokinase

6 of 7

3.16

7.27

3.81e-14

PF00349

Hexokinase

6 of 7

3.16

7.27

3.81e-14

PF03404

Mo-co oxidoreductase dimerisation domain

3 of 8

2.8

2.52

2.34e-05

PF00174

Oxidoreductase molybdopterin binding domain

3 of 8

2.8

2.52

2.34e-05

PF00970

Oxidoreductase FAD-binding domain

3 of 13

2.59

2.33

4.75e-05

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR022673

Hexokinase, C-terminal

6 of 7

3.16

7.04

1.02e-13

IPR022672

Hexokinase, N-terminal

6 of 7

3.16

7.04

1.02e-13

IPR001312

Hexokinase

6 of 7

3.16

7.04

1.02e-13

IPR043129

ATPase, nucleotide binding domain

6 of 64

2.2

4.12

1.93e-09

IPR019807

Hexokinase, binding site

3 of 4

3.1

2.81

8.00e-06

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01117

Cytochrome b5-like Heme/Steroid binding domain

3 of 41

2.09

1.53

0.0011

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (28%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About