S40285_01261 protein (Stachybotrys chlorohalonata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

S40285_01261

Uncharacterized protein. (445 aa)

Predicted Functional Partners:

S40285_00293

0.999

S40285_00148

0.923

S40285_00858

0.891

S40285_02620

0.876

S40285_04924

0.855

S40285_04559

0.855

S40285_08359

0.845

S40285_07580

0.845

S40285_04082

0.845

S40285_04087

0.845

Your Current Organism:

Stachybotrys chlorohalonata

NCBI taxonomy Id: 1283841
Other names: S. chlorohalonata IBT 40285, Stachybotrys chlorohalonata IBT 40285

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
S40285_00148	S40285_00293	A0A084QU49	A0A084QHR4	Ornithine aminotransferase.	PUA domain-containing protein.	0.920
S40285_00148	S40285_00858	A0A084QU49	A0A084QJT1	Ornithine aminotransferase.	Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.895
S40285_00148	S40285_01261	A0A084QU49	A0A084QQX9	Ornithine aminotransferase.	Uncharacterized protein.	0.923
S40285_00148	S40285_04082	A0A084QU49	A0A084QVA8	Ornithine aminotransferase.	Gln-synt_C domain-containing protein; Belongs to the glutamine synthetase family.	0.465
S40285_00148	S40285_04087	A0A084QU49	A0A084QVC6	Ornithine aminotransferase.	Glutamine synthetase.	0.531
S40285_00148	S40285_04559	A0A084QU49	A0A084QKR1	Ornithine aminotransferase.	NAD-specific glutamate dehydrogenase; NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate. Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.745
S40285_00148	S40285_04924	A0A084QU49	A0A084QGY8	Ornithine aminotransferase.	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.745
S40285_00148	S40285_07580	A0A084QU49	A0A084Q9A3	Ornithine aminotransferase.	Gln-synt_C domain-containing protein; Belongs to the glutamine synthetase family.	0.473
S40285_00293	S40285_00148	A0A084QHR4	A0A084QU49	PUA domain-containing protein.	Ornithine aminotransferase.	0.920
S40285_00293	S40285_00858	A0A084QHR4	A0A084QJT1	PUA domain-containing protein.	Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.891
S40285_00293	S40285_01261	A0A084QHR4	A0A084QQX9	PUA domain-containing protein.	Uncharacterized protein.	0.999
S40285_00293	S40285_02620	A0A084QHR4	A0A084QXH0	PUA domain-containing protein.	Glutamine amidotransferase type-2 domain-containing protein.	0.890
S40285_00293	S40285_04082	A0A084QHR4	A0A084QVA8	PUA domain-containing protein.	Gln-synt_C domain-containing protein; Belongs to the glutamine synthetase family.	0.693
S40285_00293	S40285_04087	A0A084QHR4	A0A084QVC6	PUA domain-containing protein.	Glutamine synthetase.	0.693
S40285_00293	S40285_04559	A0A084QHR4	A0A084QKR1	PUA domain-containing protein.	NAD-specific glutamate dehydrogenase; NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate. Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.815
S40285_00293	S40285_04924	A0A084QHR4	A0A084QGY8	PUA domain-containing protein.	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.815
S40285_00293	S40285_07580	A0A084QHR4	A0A084Q9A3	PUA domain-containing protein.	Gln-synt_C domain-containing protein; Belongs to the glutamine synthetase family.	0.693
S40285_00293	S40285_08359	A0A084QHR4	A0A084Q7P8	PUA domain-containing protein.	NADPH:adrenodoxin oxidoreductase, mitochondrial.	0.866
S40285_00858	S40285_00148	A0A084QJT1	A0A084QU49	Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Ornithine aminotransferase.	0.895
S40285_00858	S40285_00293	A0A084QJT1	A0A084QHR4	Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family.	PUA domain-containing protein.	0.891

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

22

PPI enrichment p-value:

2.99e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044255

Cellular lipid metabolic process

11 of 444

1.26

2.05

2.20e-11

GO:0006631

Fatty acid metabolic process

9 of 342

1.29

1.89

1.18e-08

GO:0044248

Cellular catabolic process

9 of 377

1.25

1.77

2.08e-08

GO:0010142

Farnesyl diphosphate biosynthetic process, mevalonate pathway

2 of 2

2.87

1.63

0.0011

GO:1901575

Organic substance catabolic process

9 of 517

1.11

1.38

2.23e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070403

NAD+ binding

8 of 9

2.82

8.8

7.61e-18

GO:0016616

Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

8 of 74

1.9

4.35

3.64e-12

GO:0004421

hydroxymethylglutaryl-CoA synthase activity

2 of 2

2.87

1.56

0.0015

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

10 of 2275

0.51

0.39

0.0038

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1105

Butanoate metabolism, and Thiolase, C-terminal domain

9 of 43

2.19

6.53

2.78e-16

CL:1108

3-hydroxyacyl-CoA dehydrogenase, C-terminal domain, and Limonene and pinene degradation

7 of 24

2.33

5.9

2.52e-13

CL:1098

Mixed, incl. Fatty acid degradation, and Butanoate metabolism

10 of 93

1.9

5.29

2.78e-16

CL:1109

3-hydroxyacyl-CoA dehydrogenase, C-terminal domain, and Limonene and pinene degradation

6 of 19

2.37

5.16

2.40e-11

CL:1111

3-hydroxyacyl-CoA dehydrogenase, C-terminal domain, and Thiolase, C-terminal domain

5 of 13

2.45

4.47

1.48e-09

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00650

Butanoate metabolism

9 of 66

2.0

5.54

2.26e-15

map00362

Benzoate degradation

8 of 107

1.74

3.68

1.42e-11

map00360

Phenylalanine metabolism

6 of 79

1.75

2.95

2.30e-08

map01200

Carbon metabolism

7 of 211

1.39

2.02

9.70e-08

map00280

Valine, leucine and isoleucine degradation

4 of 89

1.52

1.58

0.00012

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070062

Extracellular exosome

7 of 15

2.54

6.64

3.92e-14

GOCC:0065010

Extracellular membrane-bounded organelle

7 of 23

2.35

5.95

2.33e-13

GOCC:0043227

Membrane-bounded organelle

10 of 586

1.1

1.49

1.99e-09

GOCC:0005777

Peroxisome

3 of 129

1.24

0.75

0.0158

GOCC:0005829

Cytosol

7 of 830

0.79

0.66

0.00081

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0560

Oxidoreductase

8 of 720

0.91

0.85

0.00012

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00725

3-hydroxyacyl-CoA dehydrogenase, C-terminal domain

8 of 8

2.87

9.02

3.98e-18

PF02737

3-hydroxyacyl-CoA dehydrogenase, NAD binding domain

4 of 6

2.69

3.62

1.69e-07

PF03446

NAD binding domain of 6-phosphogluconate dehydrogenase

4 of 12

2.39

3.11

9.74e-07

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (28%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About