S40285_04984 protein (Stachybotrys chlorohalonata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

S40285_04984

DPBB_1 domain-containing protein. (121 aa)

Predicted Functional Partners:

S40285_04807

0.920

S40285_06564

0.906

S40285_07878

0.899

S40285_01863

0.888

S40285_06971

0.834

S40285_00181

0.823

S40285_05607

0.818

S40285_08787

0.814

S40285_03694

0.814

S40285_01323

0.814

Your Current Organism:

Stachybotrys chlorohalonata

NCBI taxonomy Id: 1283841
Other names: S. chlorohalonata IBT 40285, Stachybotrys chlorohalonata IBT 40285

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
S40285_00181	S40285_01863	A0A084QTU9	A0A084QQQ0	Uncharacterized protein.	Uncharacterized protein.	0.450
S40285_00181	S40285_03694	A0A084QTU9	A0A084QPZ1	Uncharacterized protein.	Uncharacterized protein.	0.999
S40285_00181	S40285_04807	A0A084QTU9	A0A084QP26	Uncharacterized protein.	MFAP1 domain-containing protein.	0.625
S40285_00181	S40285_04984	A0A084QTU9	A0A084QRW1	Uncharacterized protein.	DPBB_1 domain-containing protein.	0.823
S40285_00181	S40285_05607	A0A084QTU9	A0A084QCU4	Uncharacterized protein.	RRM domain-containing protein.	0.951
S40285_00181	S40285_06564	A0A084QTU9	A0A084QD51	Uncharacterized protein.	Uncharacterized protein.	0.823
S40285_00181	S40285_06971	A0A084QTU9	A0A084QV40	Uncharacterized protein.	Uncharacterized protein.	0.999
S40285_00181	S40285_07878	A0A084QTU9	A0A084Q986	Uncharacterized protein.	C2H2-type domain-containing protein.	0.771
S40285_00181	S40285_08787	A0A084QTU9	A0A084QIB6	Uncharacterized protein.	Uncharacterized protein.	0.980
S40285_01323	S40285_03694	A0A084QR01	A0A084QPZ1	Uncharacterized protein.	Uncharacterized protein.	0.975
S40285_01323	S40285_04984	A0A084QR01	A0A084QRW1	Uncharacterized protein.	DPBB_1 domain-containing protein.	0.814
S40285_01323	S40285_06971	A0A084QR01	A0A084QV40	Uncharacterized protein.	Uncharacterized protein.	0.961
S40285_01323	S40285_08787	A0A084QR01	A0A084QIB6	Uncharacterized protein.	Uncharacterized protein.	0.922
S40285_01863	S40285_00181	A0A084QQQ0	A0A084QTU9	Uncharacterized protein.	Uncharacterized protein.	0.450
S40285_01863	S40285_03694	A0A084QQQ0	A0A084QPZ1	Uncharacterized protein.	Uncharacterized protein.	0.633
S40285_01863	S40285_04807	A0A084QQQ0	A0A084QP26	Uncharacterized protein.	MFAP1 domain-containing protein.	0.966
S40285_01863	S40285_04984	A0A084QQQ0	A0A084QRW1	Uncharacterized protein.	DPBB_1 domain-containing protein.	0.888
S40285_01863	S40285_06564	A0A084QQQ0	A0A084QD51	Uncharacterized protein.	Uncharacterized protein.	0.504
S40285_01863	S40285_06971	A0A084QQQ0	A0A084QV40	Uncharacterized protein.	Uncharacterized protein.	0.705
S40285_01863	S40285_07878	A0A084QQQ0	A0A084Q986	Uncharacterized protein.	C2H2-type domain-containing protein.	0.472

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

49

average node degree:

8.91

avg. local clustering coefficient:

0.921

expected number of edges:

15

PPI enrichment p-value:

9.92e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006085

acetyl-CoA biosynthetic process

4 of 8

2.23

2.36

2.51e-05

GO:0019427

acetyl-CoA biosynthetic process from acetate

2 of 3

2.35

1.28

0.0042

GO:0022900

Electron transport chain

5 of 96

1.25

1.14

0.00052

GO:0006091

Generation of precursor metabolites and energy

6 of 184

1.04

0.93

0.00054

GO:0032787

Monocarboxylic acid metabolic process

4 of 113

1.08

0.72

0.0097

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030976

Thiamine pyrophosphate binding

4 of 8

2.23

2.49

1.32e-05

GO:0016208

AMP binding

2 of 3

2.35

1.15

0.0074

GO:0003987

acetate-CoA ligase activity

2 of 3

2.35

1.15

0.0074

GO:0043169

Cation binding

8 of 564

0.68

0.51

0.0037

GO:0036094

Small molecule binding

8 of 556

0.69

0.51

0.0037

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009274

Peptidoglycan-based cell wall

3 of 22

1.66

1.09

0.0055

GO:0005829

Cytosol

6 of 316

0.81

0.58

0.0065

GO:0005737

Cytoplasm

9 of 1132

0.43

0.31

0.0214

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1244

Citrate cycle (TCA cycle), and Propanoate metabolism

10 of 30

2.05

6.17

5.15e-17

CL:1245

Citrate cycle (TCA cycle)

6 of 23

1.95

3.42

1.14e-08

CL:1246

Citrate cycle (TCA cycle), and Novobiocin biosynthesis

5 of 14

2.08

3.23

1.40e-07

CL:1292

acetyl-CoA biosynthetic process

4 of 5

2.43

3.2

6.81e-07

CL:1248

Pyruvate ferredoxin/flavodoxin oxidoreductase, and Thiamine pyrophosphate enzyme, TPP-binding

4 of 7

2.29

2.96

1.52e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

daf00620

Pyruvate metabolism

11 of 38

1.99

6.53

6.02e-20

daf00650

Butanoate metabolism

5 of 14

2.08

3.58

1.76e-08

daf01200

Carbon metabolism

11 of 115

1.51

3.3

2.10e-15

daf00010

Glycolysis / Gluconeogenesis

7 of 46

1.71

3.24

6.14e-10

daf00020

Citrate cycle (TCA cycle)

5 of 22

1.89

3.03

8.64e-08

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005618

Cell wall

3 of 12

1.93

1.34

0.0023

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0460

Magnesium

4 of 98

1.14

0.71

0.0154

KW-0479

Metal-binding

6 of 263

0.89

0.61

0.0093

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02775

Thiamine pyrophosphate enzyme, C-terminal TPP binding domain

4 of 7

2.29

2.62

7.79e-06

PF01855

Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg

2 of 5

2.13

0.71

0.0481

PF01558

Pyruvate ferredoxin/flavodoxin oxidoreductase

2 of 5

2.13

0.71

0.0481

PF13193

AMP-binding enzyme C-terminal domain

2 of 7

1.99

0.7

0.0481

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR029061

Thiamin diphosphate-binding fold

5 of 16

2.02

2.68

2.24e-06

IPR011766

Thiamine pyrophosphate enzyme, TPP-binding

4 of 7

2.29

2.58

9.79e-06

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