S40285_05137 protein (Stachybotrys chlorohalonata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

S40285_05137

Uncharacterized protein. (1120 aa)

Predicted Functional Partners:

S40285_02733

0.909

S40285_00843

0.908

S40285_03649

0.897

S40285_07506

0.883

S40285_00798

0.865

S40285_08041

0.861

S40285_04986

0.861

S40285_01573

0.836

S40285_02837

0.833

S40285_01038

0.825

Your Current Organism:

Stachybotrys chlorohalonata

NCBI taxonomy Id: 1283841
Other names: S. chlorohalonata IBT 40285, Stachybotrys chlorohalonata IBT 40285

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
S40285_00798	S40285_00843	A0A084QJH7	A0A084QJP6	TUG-UBL1 domain-containing protein.	MPN domain-containing protein.	0.942
S40285_00798	S40285_02733	A0A084QJH7	A0A084QAH0	TUG-UBL1 domain-containing protein.	Uncharacterized protein.	0.988
S40285_00798	S40285_03649	A0A084QJH7	A0A084QTK4	TUG-UBL1 domain-containing protein.	UBX domain-containing protein.	0.941
S40285_00798	S40285_05137	A0A084QJH7	A0A084QSU2	TUG-UBL1 domain-containing protein.	Uncharacterized protein.	0.865
S40285_00798	S40285_07506	A0A084QJH7	A0A084QGH9	TUG-UBL1 domain-containing protein.	UBX domain-containing protein.	0.979
S40285_00798	S40285_08041	A0A084QJH7	A0A084Q8I1	TUG-UBL1 domain-containing protein.	OTU domain-containing protein.	0.642
S40285_00843	S40285_00798	A0A084QJP6	A0A084QJH7	MPN domain-containing protein.	TUG-UBL1 domain-containing protein.	0.942
S40285_00843	S40285_01038	A0A084QJP6	A0A084QKG5	MPN domain-containing protein.	VWFA domain-containing protein.	0.701
S40285_00843	S40285_01573	A0A084QJP6	A0A084QWC1	MPN domain-containing protein.	Proteasome subunit beta.	0.636
S40285_00843	S40285_02733	A0A084QJP6	A0A084QAH0	MPN domain-containing protein.	Uncharacterized protein.	0.902
S40285_00843	S40285_02837	A0A084QJP6	A0A084QDA4	MPN domain-containing protein.	26S proteasome regulatory subunit RPN1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.	0.672
S40285_00843	S40285_03649	A0A084QJP6	A0A084QTK4	MPN domain-containing protein.	UBX domain-containing protein.	0.996
S40285_00843	S40285_04986	A0A084QJP6	A0A084QRW8	MPN domain-containing protein.	PRKCSH domain-containing protein.	0.508
S40285_00843	S40285_05137	A0A084QJP6	A0A084QSU2	MPN domain-containing protein.	Uncharacterized protein.	0.908
S40285_00843	S40285_07506	A0A084QJP6	A0A084QGH9	MPN domain-containing protein.	UBX domain-containing protein.	0.954
S40285_00843	S40285_08041	A0A084QJP6	A0A084Q8I1	MPN domain-containing protein.	OTU domain-containing protein.	0.962
S40285_01038	S40285_00843	A0A084QKG5	A0A084QJP6	VWFA domain-containing protein.	MPN domain-containing protein.	0.701
S40285_01038	S40285_01573	A0A084QKG5	A0A084QWC1	VWFA domain-containing protein.	Proteasome subunit beta.	0.998
S40285_01038	S40285_02733	A0A084QKG5	A0A084QAH0	VWFA domain-containing protein.	Uncharacterized protein.	0.587
S40285_01038	S40285_02837	A0A084QKG5	A0A084QDA4	VWFA domain-containing protein.	26S proteasome regulatory subunit RPN1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.	0.999

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

30

average node degree:

5.45

avg. local clustering coefficient:

0.848

expected number of edges:

11

PPI enrichment p-value:

7.77e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045116

Protein neddylation

4 of 6

3.02

4.15

2.39e-08

GO:0032446

Protein modification by small protein conjugation

8 of 195

1.81

3.61

2.01e-10

GO:0019941

Modification-dependent protein catabolic process

5 of 249

1.5

0.00018

GO:0016567

Protein ubiquitination

4 of 176

1.55

1.3

0.0011

GO:0006511

Ubiquitin-dependent protein catabolic process

4 of 241

1.41

1.04

0.0036

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031625

Ubiquitin protein ligase binding

4 of 31

2.3

2.63

8.04e-06

GO:0019788

NEDD8 transferase activity

2 of 2

3.19

1.6

0.0013

GO:0019787

Ubiquitin-like protein transferase activity

3 of 145

1.51

0.72

0.0334

GO:0005515

Protein binding

5 of 886

0.94

0.52

0.0376

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031463

Cul3-RING ubiquitin ligase complex

3 of 3

3.19

3.02

3.32e-06

GO:0031461

cullin-RING ubiquitin ligase complex

4 of 54

2.06

2.35

1.62e-05

GO:0019005

SCF ubiquitin ligase complex

2 of 22

2.15

0.98

0.0147

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2918

Protein neddylation, and SCF ubiquitin ligase complex

7 of 19

2.76

7.48

3.06e-15

CL:2914

cullin-RING ubiquitin ligase complex, and COP9 signalosome

8 of 42

2.47

7.15

1.16e-15

CL:2941

Protein neddylation

3 of 5

2.97

2.93

4.46e-06

CL:2920

Mixed, incl. Nuclear SCF ubiquitin ligase complex, and Cullin

2 of 10

2.49

1.13

0.0086

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04120

Ubiquitin mediated proteolysis

7 of 131

1.92

4.01

9.32e-11

map04141

Protein processing in endoplasmic reticulum

3 of 221

1.32

0.71

0.0259

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8951664

Neddylation

6 of 131

1.85

2.96

1.00e-07

MAP-9013422

RHOBTB1 GTPase cycle

2 of 20

2.19

0.91

0.0206

MAP-9013418

RHOBTB2 GTPase cycle

2 of 24

2.11

0.9

0.0206

MAP-597592

Post-translational protein modification

6 of 798

1.07

0.86

0.0019

MAP-9706574

RHOBTB GTPase Cycle

2 of 32

1.99

0.82

0.0285

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031463

Cul3-RING ubiquitin ligase complex

3 of 3

3.19

3.14

1.99e-06

GOCC:0031461

cullin-RING ubiquitin ligase complex

5 of 65

2.08

3.02

4.52e-07

GOCC:1902494

Catalytic complex

7 of 954

1.06

1.03

0.00012

GOCC:0019005

SCF ubiquitin ligase complex

2 of 37

1.93

0.71

0.0463

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR045093

Cullin

3 of 4

3.07

2.57

2.20e-05

IPR001373

Cullin, N-terminal

3 of 5

2.97

2.56

2.20e-05

IPR016159

Cullin repeat-like-containing domain superfamily

3 of 6

2.89

2.55

2.20e-05

IPR019559

Cullin protein, neddylation domain

2 of 3

3.02

1.4

0.0030

IPR036317

Cullin homology domain superfamily

2 of 4

2.89

1.35

0.0036

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00884

Cullin protein neddylation domain

2 of 3

3.02

1.6

0.0013

SM00182

Cullin

2 of 3

3.02

1.6

0.0013

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (30%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About