S40285_03001 protein (Stachybotrys chlorohalonata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

S40285_03001

Uncharacterized protein. (291 aa)

Predicted Functional Partners:

S40285_05165

0.632

S40285_01535

0.620

S40285_02755

0.603

S40285_06102

0.597

S40285_04736

0.532

S40285_00452

0.532

S40285_08261

0.532

S40285_02997

0.524

S40285_00114

0.518

S40285_06379

0.512

Your Current Organism:

Stachybotrys chlorohalonata

NCBI taxonomy Id: 1283841
Other names: S. chlorohalonata IBT 40285, Stachybotrys chlorohalonata IBT 40285

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
S40285_00114	S40285_02755	A0A084QZ32	A0A084QAG6	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family.	UBA domain-containing protein.	0.455
S40285_00114	S40285_03001	A0A084QZ32	A0A084QSZ6	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family.	Uncharacterized protein.	0.518
S40285_00114	S40285_06379	A0A084QZ32	A0A084QEE9	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family.	Uncharacterized protein.	0.467
S40285_00452	S40285_03001	A0A084QNE0	A0A084QSZ6	Uncharacterized protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	Uncharacterized protein.	0.532
S40285_00452	S40285_04736	A0A084QNE0	A0A084Q9W8	Uncharacterized protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	Uncharacterized protein.	0.878
S40285_00452	S40285_06379	A0A084QNE0	A0A084QEE9	Uncharacterized protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	Uncharacterized protein.	0.905
S40285_00452	S40285_08261	A0A084QNE0	A0A084R211	Uncharacterized protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	Uncharacterized protein.	0.870
S40285_01535	S40285_03001	A0A084QML4	A0A084QSZ6	Uncharacterized protein.	Uncharacterized protein.	0.620
S40285_01535	S40285_05165	A0A084QML4	A0A084QF88	Uncharacterized protein.	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.812
S40285_01535	S40285_06379	A0A084QML4	A0A084QEE9	Uncharacterized protein.	Uncharacterized protein.	0.651
S40285_02755	S40285_00114	A0A084QAG6	A0A084QZ32	UBA domain-containing protein.	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family.	0.455
S40285_02755	S40285_03001	A0A084QAG6	A0A084QSZ6	UBA domain-containing protein.	Uncharacterized protein.	0.603
S40285_02755	S40285_06379	A0A084QAG6	A0A084QEE9	UBA domain-containing protein.	Uncharacterized protein.	0.470
S40285_02997	S40285_03001	A0A084QT33	A0A084QSZ6	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.524
S40285_03001	S40285_00114	A0A084QSZ6	A0A084QZ32	Uncharacterized protein.	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family.	0.518
S40285_03001	S40285_00452	A0A084QSZ6	A0A084QNE0	Uncharacterized protein.	Uncharacterized protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	0.532
S40285_03001	S40285_01535	A0A084QSZ6	A0A084QML4	Uncharacterized protein.	Uncharacterized protein.	0.620
S40285_03001	S40285_02755	A0A084QSZ6	A0A084QAG6	Uncharacterized protein.	UBA domain-containing protein.	0.603
S40285_03001	S40285_02997	A0A084QSZ6	A0A084QT33	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.524
S40285_03001	S40285_04736	A0A084QSZ6	A0A084Q9W8	Uncharacterized protein.	Uncharacterized protein.	0.532

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

31

average node degree:

5.64

avg. local clustering coefficient:

0.818

expected number of edges:

22

PPI enrichment p-value:

0.0447

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006189

De novo IMP biosynthetic process

10 of 11

2.34

7.95

8.08e-19

GO:0006164

Purine nucleotide biosynthetic process

11 of 44

1.78

4.9

1.69e-17

GO:0006541

Glutamine metabolic process

2 of 14

1.54

0.71

0.0349

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004642

Phosphoribosylformylglycinamidine synthase activity

3 of 3

2.38

1.98

0.00019

GO:0016879

Ligase activity, forming carbon-nitrogen bonds

6 of 49

1.47

1.76

1.38e-05

GO:0016742

Hydroxymethyl-, formyl- and related transferase activity

2 of 4

2.08

1.06

0.0099

GO:0005524

ATP binding

7 of 303

0.75

0.52

0.0080

GO:0003824

Catalytic activity

11 of 1264

0.32

0.27

0.0114

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

10 of 940

0.41

0.3

0.0236

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:844

De novo IMP biosynthetic process

11 of 11

2.38

9.28

3.50e-22

CL:846

De novo IMP biosynthetic process

6 of 6

2.38

5.0

6.34e-11

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00230

Purine metabolism

11 of 93

1.46

2.98

1.98e-14

map01110

Biosynthesis of secondary metabolites

11 of 293

0.96

1.17

1.90e-09

map01100

Metabolic pathways

11 of 898

0.47

0.4

0.00024

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005829

Cytosol

8 of 298

0.81

0.7

0.00037

GOCC:0005737

Cytoplasm

11 of 647

0.61

0.54

4.23e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0658

Purine biosynthesis

11 of 16

2.22

8.21

1.86e-21

KW-0436

Ligase

7 of 84

1.3

1.69

1.09e-06

KW-0067

ATP-binding

7 of 253

0.83

0.68

0.0010

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02769

AIR synthase related protein, C-terminal domain

2 of 2

2.38

0.79

0.0357

PF00586

AIR synthase related protein, N-terminal domain

2 of 2

2.38

0.79

0.0357

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