S40285_06950 protein (Stachybotrys chlorohalonata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

S40285_06950

Profilin; Belongs to the profilin family. (127 aa)

Predicted Functional Partners:

S40285_05534

0.987

S40285_04443

0.976

S40285_02792

0.941

S40285_08355

0.925

S40285_02985

0.894

S40285_03552

0.881

S40285_03231

0.878

S40285_07616

0.862

S40285_02974

0.859

S40285_07239

0.857

Your Current Organism:

Stachybotrys chlorohalonata

NCBI taxonomy Id: 1283841
Other names: S. chlorohalonata IBT 40285, Stachybotrys chlorohalonata IBT 40285

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
S40285_02792	S40285_02974	A0A084QAK2	A0A084QSZ1	Uncharacterized protein.	Uncharacterized protein.	0.559
S40285_02792	S40285_02985	A0A084QAK2	A0A084QT29	Uncharacterized protein.	Uncharacterized protein; Belongs to the actin family.	0.620
S40285_02792	S40285_03231	A0A084QAK2	A0A084QNM0	Uncharacterized protein.	Uncharacterized protein; Belongs to the actin family.	0.526
S40285_02792	S40285_03552	A0A084QAK2	A0A084QVM0	Uncharacterized protein.	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	0.620
S40285_02792	S40285_04443	A0A084QAK2	A0A084QIS8	Uncharacterized protein.	Uncharacterized protein; Belongs to the actin family.	0.840
S40285_02792	S40285_05534	A0A084QAK2	A0A084QBD5	Uncharacterized protein.	Uncharacterized protein.	0.974
S40285_02792	S40285_06950	A0A084QAK2	A0A084QV37	Uncharacterized protein.	Profilin; Belongs to the profilin family.	0.941
S40285_02974	S40285_02792	A0A084QSZ1	A0A084QAK2	Uncharacterized protein.	Uncharacterized protein.	0.559
S40285_02974	S40285_02985	A0A084QSZ1	A0A084QT29	Uncharacterized protein.	Uncharacterized protein; Belongs to the actin family.	0.905
S40285_02974	S40285_03231	A0A084QSZ1	A0A084QNM0	Uncharacterized protein.	Uncharacterized protein; Belongs to the actin family.	0.900
S40285_02974	S40285_03552	A0A084QSZ1	A0A084QVM0	Uncharacterized protein.	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	0.883
S40285_02974	S40285_04443	A0A084QSZ1	A0A084QIS8	Uncharacterized protein.	Uncharacterized protein; Belongs to the actin family.	0.976
S40285_02974	S40285_05534	A0A084QSZ1	A0A084QBD5	Uncharacterized protein.	Uncharacterized protein.	0.976
S40285_02974	S40285_06950	A0A084QSZ1	A0A084QV37	Uncharacterized protein.	Profilin; Belongs to the profilin family.	0.859
S40285_02974	S40285_07239	A0A084QSZ1	A0A084QGE5	Uncharacterized protein.	DUF1708 domain-containing protein.	0.559
S40285_02974	S40285_07616	A0A084QSZ1	A0A084QAX2	Uncharacterized protein.	Uncharacterized protein.	0.559
S40285_02974	S40285_08355	A0A084QSZ1	A0A084Q7P1	Uncharacterized protein.	Adenylyl cyclase-associated protein; Belongs to the CAP family.	0.686
S40285_02985	S40285_02792	A0A084QT29	A0A084QAK2	Uncharacterized protein; Belongs to the actin family.	Uncharacterized protein.	0.620
S40285_02985	S40285_02974	A0A084QT29	A0A084QSZ1	Uncharacterized protein; Belongs to the actin family.	Uncharacterized protein.	0.905
S40285_02985	S40285_03552	A0A084QT29	A0A084QVM0	Uncharacterized protein; Belongs to the actin family.	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	0.999

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Network Stats

number of nodes:

11

number of edges:

14

average node degree:

2.55

avg. local clustering coefficient:

0.887

expected number of edges:

10

PPI enrichment p-value:

0.15

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019265

Glycine biosynthetic process, by transamination of glyoxylate

2 of 4

2.93

1.35

0.0036

GO:0006097

Glyoxylate cycle

2 of 4

2.93

1.35

0.0036

GO:0009070

Serine family amino acid biosynthetic process

3 of 50

2.01

1.29

0.0032

GO:0019287

Isopentenyl diphosphate biosynthetic process, mevalonate pathway

2 of 6

2.75

1.26

0.0051

GO:0019752

Carboxylic acid metabolic process

7 of 1025

1.06

0.91

0.00098

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008453

Alanine-glyoxylate transaminase activity

2 of 2

3.23

1.3

0.0045

GO:0004760

Serine-pyruvate transaminase activity

2 of 2

3.23

1.3

0.0045

GO:0004474

Malate synthase activity

2 of 4

2.93

1.3

0.0045

GO:0004163

Diphosphomevalonate decarboxylase activity

2 of 2

3.23

1.3

0.0045

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005777

Peroxisome

6 of 162

1.8

2.75

2.24e-07

GO:0005782

Peroxisomal matrix

3 of 29

2.24

1.87

0.00026

GO:0009514

Glyoxysome

2 of 4

2.93

1.66

0.00097

GO:0005737

Cytoplasm

11 of 8012

0.37

0.28

0.0162

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:21300

Mixed, incl. D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain, and Glyoxysome

5 of 43

2.29

3.44

1.33e-07

CL:21309

Glycerate kinase activity, and D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site

2 of 6

2.75

1.12

0.0094

CL:21438

Glycine biosynthetic process, by transamination of glyoxylate, and Threonine dehydratase, biosynthetic

2 of 8

2.63

1.07

0.0113

CL:21353

Mixed, incl. Glyoxysome, and Alpha-hydroxy acid dehydrogenase, FMN-dependent

2 of 15

2.35

0.9

0.0227

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00630

Glyoxylate and dicarboxylate metabolism

7 of 132

1.95

4.16

5.59e-11

map01200

Carbon metabolism

7 of 349

1.53

2.46

2.13e-08

map00680

Methane metabolism

4 of 82

1.92

2.43

5.34e-06

map00260

Glycine, serine and threonine metabolism

4 of 148

1.66

1.86

4.21e-05

map04146

Peroxisome

4 of 207

1.51

1.56

0.00013

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9033241

Peroxisomal protein import

5 of 283

1.48

1.39

0.00037

MAP-389661

Glyoxylate metabolism and glycine degradation

3 of 68

1.87

1.27

0.0029

MAP-446199

Synthesis of Dolichyl-phosphate

2 of 10

2.53

1.25

0.0052

MAP-9609507

Protein localization

5 of 430

1.29

1.08

0.0014

MAP-71291

Metabolism of amino acids and derivatives

4 of 518

1.12

0.6

0.0346

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0329

Glyoxylate bypass

2 of 2

3.23

1.81

0.00054

KW-0756

Sterol biosynthesis

2 of 12

2.45

1.3

0.0041

KW-0816

Tricarboxylic acid cycle

2 of 18

2.27

1.28

0.0041

KW-0663

Pyridoxal phosphate

2 of 57

1.77

0.88

0.0189

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01274

Malate synthase

2 of 2

3.23

1.26

0.0053

PF00288

GHMP kinases N terminal domain

2 of 10

2.53

0.85

0.0290

PF00266

Aminotransferase class-V

2 of 13

2.42

0.83

0.0307

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR046363

Malate synthase, N-terminal and TIM-barrel domains

2 of 2

3.23

1.03

0.0142

IPR044856

Malate synthase, C-terminal superfamily

2 of 2

3.23

1.03

0.0142

IPR041431

Mvd1, C-terminal

2 of 2

3.23

1.03

0.0142

IPR029765

Diphosphomevalonate decarboxylase

2 of 2

3.23

1.03

0.0142

IPR024169

Serine-pyruvate aminotransferase/2-aminoethylphosphonate-pyruvate transaminase

2 of 2

3.23

1.03

0.0142

(more ...)

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