S40285_07007 protein (Stachybotrys chlorohalonata)

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

S40285_07007

Lysophospholipase. (654 aa)

Predicted Functional Partners:

S40285_06379

0.808

S40285_06697

0.806

S40285_00447

0.805

S40285_02648

0.801

S40285_09566

0.746

S40285_00087

0.746

S40285_05791

0.558

S40285_05852

0.558

S40285_03589

0.558

S40285_09068

0.558

Your Current Organism:

Stachybotrys chlorohalonata

NCBI taxonomy Id: 1283841
Other names: S. chlorohalonata IBT 40285, Stachybotrys chlorohalonata IBT 40285

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
S40285_00087	S40285_00447	A0A084QYV8	A0A084QN52	Lysophospholipase.	Uncharacterized protein; Belongs to the membrane-bound acyltransferase family.	0.761
S40285_00087	S40285_02648	A0A084QYV8	A0A084QXM2	Lysophospholipase.	Uncharacterized protein.	0.801
S40285_00087	S40285_03589	A0A084QYV8	A0A084QBS7	Lysophospholipase.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.558
S40285_00087	S40285_05791	A0A084QYV8	A0A084QAE8	Lysophospholipase.	Uncharacterized protein.	0.558
S40285_00087	S40285_05852	A0A084QYV8	A0A084QBL1	Lysophospholipase.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.558
S40285_00087	S40285_06379	A0A084QYV8	A0A084QEE9	Lysophospholipase.	Uncharacterized protein.	0.808
S40285_00087	S40285_06697	A0A084QYV8	A0A084QA37	Lysophospholipase.	Lysophospholipase NTE1; Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis.	0.763
S40285_00087	S40285_07007	A0A084QYV8	A0A084QYC3	Lysophospholipase.	Lysophospholipase.	0.746
S40285_00087	S40285_09068	A0A084QYV8	A0A084QCA3	Lysophospholipase.	Protein kinase domain-containing protein.	0.558
S40285_00447	S40285_00087	A0A084QN52	A0A084QYV8	Uncharacterized protein; Belongs to the membrane-bound acyltransferase family.	Lysophospholipase.	0.761
S40285_00447	S40285_02648	A0A084QN52	A0A084QXM2	Uncharacterized protein; Belongs to the membrane-bound acyltransferase family.	Uncharacterized protein.	0.812
S40285_00447	S40285_06379	A0A084QN52	A0A084QEE9	Uncharacterized protein; Belongs to the membrane-bound acyltransferase family.	Uncharacterized protein.	0.834
S40285_00447	S40285_06697	A0A084QN52	A0A084QA37	Uncharacterized protein; Belongs to the membrane-bound acyltransferase family.	Lysophospholipase NTE1; Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis.	0.813
S40285_00447	S40285_07007	A0A084QN52	A0A084QYC3	Uncharacterized protein; Belongs to the membrane-bound acyltransferase family.	Lysophospholipase.	0.805
S40285_00447	S40285_09566	A0A084QN52	A0A084QJ20	Uncharacterized protein; Belongs to the membrane-bound acyltransferase family.	Lysophospholipase.	0.761
S40285_02648	S40285_00087	A0A084QXM2	A0A084QYV8	Uncharacterized protein.	Lysophospholipase.	0.801
S40285_02648	S40285_00447	A0A084QXM2	A0A084QN52	Uncharacterized protein.	Uncharacterized protein; Belongs to the membrane-bound acyltransferase family.	0.812
S40285_02648	S40285_06379	A0A084QXM2	A0A084QEE9	Uncharacterized protein.	Uncharacterized protein.	0.946
S40285_02648	S40285_06697	A0A084QXM2	A0A084QA37	Uncharacterized protein.	Lysophospholipase NTE1; Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis.	0.880
S40285_02648	S40285_07007	A0A084QXM2	A0A084QYC3	Uncharacterized protein.	Lysophospholipase.	0.801

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

33

average node degree:

6

avg. local clustering coefficient:

0.934

expected number of edges:

11

PPI enrichment p-value:

1.52e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006378

mRNA polyadenylation

6 of 14

2.33

4.34

1.48e-09

GO:0006379

mRNA cleavage

4 of 15

2.13

2.34

2.16e-05

GO:0006303

Double-strand break repair via nonhomologous end joining

4 of 19

2.02

2.16

4.09e-05

GO:0071481

Cellular response to X-ray

2 of 2

2.7

1.33

0.0038

GO:0071480

Cellular response to gamma radiation

2 of 2

2.7

1.33

0.0038

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003684

Damaged DNA binding

3 of 22

1.84

1.05

0.0087

GO:0003676

Nucleic acid binding

9 of 914

0.69

0.51

0.0050

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005849

mRNA cleavage factor complex

6 of 16

2.28

4.4

7.26e-10

GO:0005847

mRNA cleavage and polyadenylation specificity factor complex

5 of 13

2.29

3.68

3.85e-08

GO:0043564

Ku70:Ku80 complex

2 of 2

2.7

1.45

0.0023

GO:0140513

Nuclear protein-containing complex

10 of 622

0.91

0.98

9.84e-07

GO:0000785

Chromatin

6 of 288

1.02

0.86

0.0011

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4200

mRNA polyadenylation, and PTW/PP1 phosphatase complex

6 of 17

2.25

4.29

1.09e-09

CL:2752

Non-homologous end-joining

4 of 5

2.6

3.43

3.34e-07

CL:4201

mRNA cleavage and polyadenylation specificity factor complex, and PTW/PP1 phosphatase complex

4 of 10

2.3

2.91

1.98e-06

CL:4204

Beta-Casp domain, and mRNA cleavage and polyadenylation specificity factor complex

2 of 5

2.3

1.11

0.0089

CL:4221

mRNA polyadenylation

2 of 6

2.22

1.06

0.0105

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03450

Non-homologous end-joining

4 of 11

2.26

3.07

7.83e-07

map03015

mRNA surveillance pathway

7 of 71

1.7

3.02

3.63e-09

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-77595

Processing of Intronless Pre-mRNAs

5 of 16

2.2

3.29

1.85e-07

MAP-75067

Processing of Capped Intronless Pre-mRNA

5 of 19

2.12

3.21

1.92e-07

MAP-73856

RNA Polymerase II Transcription Termination

3 of 26

1.76

1.1

0.0060

MAP-72203

Processing of Capped Intron-Containing Pre-mRNA

5 of 194

1.11

0.79

0.0060

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005849

mRNA cleavage factor complex

6 of 16

2.28

4.39

7.58e-10

GOCC:0005847

mRNA cleavage and polyadenylation specificity factor complex

5 of 12

2.32

3.76

2.91e-08

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02735

Ku70/Ku80 beta-barrel domain

2 of 2

2.7

1.01

0.0146

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR016194

SPOC-like, C-terminal domain superfamily

2 of 2

2.7

0.75

0.0435

IPR006164

Ku70/Ku80 beta-barrel domain

2 of 2

2.7

0.75

0.0435

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