| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AJC95537.1 | glyA | SHYC_03710 | SHYC_03715 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0340 family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.830 |
| AJC95537.1 | lacA | SHYC_03710 | SHYC_03350 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0340 family. | Galactose-6-phosphate isomerase subunit LacA; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.640 |
| AJC95537.1 | lacB | SHYC_03710 | SHYC_03355 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0340 family. | Galactose-6-phosphate isomerase subunit LacB; Catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.879 |
| AJC95537.1 | upp | SHYC_03710 | SHYC_03720 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0340 family. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.799 |
| glyA | AJC95537.1 | SHYC_03715 | SHYC_03710 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0340 family. | 0.830 |
| glyA | lacB | SHYC_03715 | SHYC_03355 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Galactose-6-phosphate isomerase subunit LacB; Catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.903 |
| glyA | upp | SHYC_03715 | SHYC_03720 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.955 |
| lacA | AJC95537.1 | SHYC_03350 | SHYC_03710 | Galactose-6-phosphate isomerase subunit LacA; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0340 family. | 0.640 |
| lacA | lacB | SHYC_03350 | SHYC_03355 | Galactose-6-phosphate isomerase subunit LacA; Derived by automated computational analysis using gene prediction method: Protein Homology. | Galactose-6-phosphate isomerase subunit LacB; Catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.993 |
| lacA | lacC | SHYC_03350 | SHYC_07525 | Galactose-6-phosphate isomerase subunit LacA; Derived by automated computational analysis using gene prediction method: Protein Homology. | Tagatose-6-phosphate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. | 0.976 |
| lacA | lacD | SHYC_03350 | SHYC_03360 | Galactose-6-phosphate isomerase subunit LacA; Derived by automated computational analysis using gene prediction method: Protein Homology. | Tagatose-bisphosphate aldolase; Catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.939 |
| lacA | lacE | SHYC_03350 | SHYC_03370 | Galactose-6-phosphate isomerase subunit LacA; Derived by automated computational analysis using gene prediction method: Protein Homology. | PTS system lactose-specific transporter subunits IICB; Phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.900 |
| lacA | lacF | SHYC_03350 | SHYC_03365 | Galactose-6-phosphate isomerase subunit LacA; Derived by automated computational analysis using gene prediction method: Protein Homology. | PTS system lactose-specific transporter subunit IIA; Catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.796 |
| lacA | lacG | SHYC_03350 | SHYC_03375 | Galactose-6-phosphate isomerase subunit LacA; Derived by automated computational analysis using gene prediction method: Protein Homology. | 6-phospho-beta-galactosidase; Catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glycosyl hydrolase 1 family. | 0.970 |
| lacA | pfkA | SHYC_03350 | SHYC_06140 | Galactose-6-phosphate isomerase subunit LacA; Derived by automated computational analysis using gene prediction method: Protein Homology. | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. | 0.917 |
| lacB | AJC95537.1 | SHYC_03355 | SHYC_03710 | Galactose-6-phosphate isomerase subunit LacB; Catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0340 family. | 0.879 |
| lacB | glyA | SHYC_03355 | SHYC_03715 | Galactose-6-phosphate isomerase subunit LacB; Catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.903 |
| lacB | lacA | SHYC_03355 | SHYC_03350 | Galactose-6-phosphate isomerase subunit LacB; Catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Galactose-6-phosphate isomerase subunit LacA; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.993 |
| lacB | lacC | SHYC_03355 | SHYC_07525 | Galactose-6-phosphate isomerase subunit LacB; Catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Tagatose-6-phosphate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. | 0.976 |
| lacB | lacD | SHYC_03355 | SHYC_03360 | Galactose-6-phosphate isomerase subunit LacB; Catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | Tagatose-bisphosphate aldolase; Catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.949 |