STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rsbWSerine-protein kinase RsbW; Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B). (159 aa)    
Predicted Functional Partners:
rsbV
anti-sigma-B factor antagonist; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the anti-sigma-factor antagonist family.
 
 
 0.999
sigB
RNA polymerase sigma factor SigB; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
 
 
 0.998
rsbU
Phosphoserine phosphatase RsbU; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.997
mazF
mRNA interferase MazF; Toxic component of a type II toxin-antitoxin (TA) system.
 
  
 0.797
mazE
Antitoxin MazE; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.766
tex
S1 RNA-binding domain-containing transcription accessory protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.753
AJC95585.1
SprT family protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SprT family.
       0.753
prkC
Serine/threonine-protein kinase PrkC; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 
 0.669
alr
Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family.
  
    0.660
AJC95687.1
Membrane bound metal dependent hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.623
Your Current Organism:
Staphylococcus hyicus
NCBI taxonomy Id: 1284
Other names: ATCC 11249, CCM 2368, CCUG 6509, CIP 81.58, DSM 20459, JCM 2423, LMG 13352, LMG:13352, Micrococcus hyicus, NCTC 10350, S. hyicus, Staphylococcus hyicus hyicus, Staphylococcus hyicus subsp. hyicus
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