STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aurZinc metalloproteinase precursor/aureolysin; Extracellular zinc metalloprotease. (501 aa)    
Predicted Functional Partners:
scpA
Segregation and condensation protein A; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.
      
 0.742
sspP
Staphopain A cysteine protease; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.705
nuc
Thermonuclease; Enzyme that catalyzes the hydrolysis of both DNA and RNA at the 5'-position of the phosphodiester bond.
      
 0.670
AJC96557.1
Autolysin; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
  
 0.598
sipA
Signal peptidase I; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S26 family.
      
 0.559
fnbA
Fibronectin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.555
mprF
Phosphatidylglycerol lysyltransferase; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.
  
   
 0.540
spsB-1
Signal peptidase IB; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S26 family.
      
 0.534
AJC96700.1
N-acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.504
AJC95492.1
Hemolysin III family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.456
Your Current Organism:
Staphylococcus hyicus
NCBI taxonomy Id: 1284
Other names: ATCC 11249, CCM 2368, CCUG 6509, CIP 81.58, DSM 20459, JCM 2423, LMG 13352, LMG:13352, Micrococcus hyicus, NCTC 10350, S. hyicus, Staphylococcus hyicus hyicus, Staphylococcus hyicus subsp. hyicus
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