| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AJC96480.1 | AJC96868.1 | SHYC_08725 | SHYC_10700 | Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Putative heme peroxidase; May function as heme-dependent peroxidase. | 0.567 |
| AJC96480.1 | ctaA | SHYC_08725 | SHYC_08735 | Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Heme A synthase; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 1 subfamily. | 0.881 |
| AJC96480.1 | ctaB | SHYC_08725 | SHYC_08730 | Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group; Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily. | 0.878 |
| AJC96868.1 | AJC96480.1 | SHYC_10700 | SHYC_08725 | Putative heme peroxidase; May function as heme-dependent peroxidase. | Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.567 |
| AJC96868.1 | addB | SHYC_10700 | SHYC_09445 | Putative heme peroxidase; May function as heme-dependent peroxidase. | ATP-dependent helicase/nuclease subunit B; ATP-dependent DNA helicase. | 0.529 |
| AJC96868.1 | ctaA | SHYC_10700 | SHYC_08735 | Putative heme peroxidase; May function as heme-dependent peroxidase. | Heme A synthase; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 1 subfamily. | 0.526 |
| AJC96868.1 | ctaB | SHYC_10700 | SHYC_08730 | Putative heme peroxidase; May function as heme-dependent peroxidase. | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group; Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily. | 0.935 |
| AJC96868.1 | hemH | SHYC_10700 | SHYC_05565 | Putative heme peroxidase; May function as heme-dependent peroxidase. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.985 |
| AJC96868.1 | hemY | SHYC_10700 | SHYC_05570 | Putative heme peroxidase; May function as heme-dependent peroxidase. | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | 0.744 |
| AJC96868.1 | isdI | SHYC_10700 | SHYC_11695 | Putative heme peroxidase; May function as heme-dependent peroxidase. | Heme-degrading monooxygenase IsdI; Iron regulated; catalyzes the release of heme from hemoglobin allowing bacterial pathogens to use the host heme as an iron source; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.920 |
| AJC96868.1 | lipL | SHYC_10700 | SHYC_10710 | Putative heme peroxidase; May function as heme-dependent peroxidase. | octanoyl-[GcvH]:protein N-octanoyltransferase; Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes; Belongs to the octanoyltransferase LipL family. | 0.670 |
| AJC96868.1 | pta | SHYC_10700 | SHYC_10705 | Putative heme peroxidase; May function as heme-dependent peroxidase. | Phosphotransacetylase; In Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.670 |
| AJC96868.1 | thiI | SHYC_10700 | SHYC_06050 | Putative heme peroxidase; May function as heme-dependent peroxidase. | Putative tRNA sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.528 |
| addB | AJC96868.1 | SHYC_09445 | SHYC_10700 | ATP-dependent helicase/nuclease subunit B; ATP-dependent DNA helicase. | Putative heme peroxidase; May function as heme-dependent peroxidase. | 0.529 |
| addB | thiI | SHYC_09445 | SHYC_06050 | ATP-dependent helicase/nuclease subunit B; ATP-dependent DNA helicase. | Putative tRNA sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.526 |
| ctaA | AJC96480.1 | SHYC_08735 | SHYC_08725 | Heme A synthase; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 1 subfamily. | Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.881 |
| ctaA | AJC96868.1 | SHYC_08735 | SHYC_10700 | Heme A synthase; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 1 subfamily. | Putative heme peroxidase; May function as heme-dependent peroxidase. | 0.526 |
| ctaA | ctaB | SHYC_08735 | SHYC_08730 | Heme A synthase; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 1 subfamily. | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group; Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily. | 0.997 |
| ctaA | hemH | SHYC_08735 | SHYC_05565 | Heme A synthase; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 1 subfamily. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.648 |
| ctaA | hemY | SHYC_08735 | SHYC_05570 | Heme A synthase; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 1 subfamily. | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | 0.485 |