| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| apt | deoD | SHYC_06395 | SHYC_03585 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Purine nucleoside phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.905 |
| apt | gmk | SHYC_06395 | SHYC_08380 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.941 |
| apt | guaA | SHYC_06395 | SHYC_11770 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.978 |
| apt | guaB | SHYC_06395 | SHYC_11775 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.445 |
| apt | guaC | SHYC_06395 | SHYC_07710 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanosine 5'-monophosphate oxidoreductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.923 |
| apt | hpt | SHYC_06395 | SHYC_11195 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Hypoxanthine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.930 |
| apt | pnp-1 | SHYC_06395 | SHYC_00725 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Purine-nucleoside phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.905 |
| apt | xpt | SHYC_06395 | SHYC_11785 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.923 |
| deoD | apt | SHYC_03585 | SHYC_06395 | Purine nucleoside phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.905 |
| deoD | hpt | SHYC_03585 | SHYC_11195 | Purine nucleoside phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypoxanthine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.910 |
| deoD | pnp-1 | SHYC_03585 | SHYC_00725 | Purine nucleoside phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Purine-nucleoside phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.901 |
| deoD | xpt | SHYC_03585 | SHYC_11785 | Purine nucleoside phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.905 |
| gmk | apt | SHYC_08380 | SHYC_06395 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.941 |
| gmk | guaA | SHYC_08380 | SHYC_11770 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.965 |
| gmk | guaB | SHYC_08380 | SHYC_11775 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.438 |
| gmk | guaC | SHYC_08380 | SHYC_07710 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Guanosine 5'-monophosphate oxidoreductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.914 |
| gmk | hpt | SHYC_08380 | SHYC_11195 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Hypoxanthine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.934 |
| gmk | xpt | SHYC_08380 | SHYC_11785 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.950 |
| guaA | apt | SHYC_11770 | SHYC_06395 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.978 |
| guaA | gmk | SHYC_11770 | SHYC_08380 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.965 |