STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AMG95679.1Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (433 aa)    
Predicted Functional Partners:
agrB
Accessory regulator AgrB; Essential for the production of a quorum sensing system signal molecule, the autoinducing peptide (AIP). This quorum sensing system is responsible for the regulation of the expression of virulence factor genes. Involved in the proteolytic processing of AgrD, the precursor of AIP; Belongs to the AgrB family.
 
 
 0.998
agrA
Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.997
agrD
Cyclic lactone autoinducer peptide; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.962
DltD
D-alanyl-lipoteichoic acid biosynthesis protein DltD; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.557
dltC
D-alanine--poly(phosphoribitol) ligase subunit 2; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
  
 
 0.550
rlmH
23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family.
  
    0.529
AMG97310.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
 
     0.511
prs
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
  
 0.507
zwf
Glucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone.
   
 
 0.491
AMG95373.1
Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
   0.484
Your Current Organism:
Staphylococcus simulans
NCBI taxonomy Id: 1286
Other names: ATCC 27848, CCUG 7327 A, CIP 81.64, DSM 20322, HAMBI 2058, JCM 2424, NCTC 11046, NRRL B-14753, S. simulans
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