[ The below analysis is limited to the network nodes included in the specified statistical background ]
Network Stats
average node degree:
6.91
avg. local clustering coefficient:
0.895
expected number of edges:
11
PPI enrichment p-value:
6.77e-11
your network has significantly more interactions
than expected (what does that mean?)
Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns
Biological Process (Gene Ontology)
Phosphorelay signal transduction system
1.37
0.66
Reference Publications (PubMed)
(2022) Increase in Ribosomal Fidelity Benefits Salmonella upon Bile Salt Exposure.
2.3
2.3
(2023) Outer Membrane Porins Contribute to Antimicrobial Resistance in Gram-Negative Bacteria.
1.97
2.24
(2015) Bacterial amyloid formation: structural insights into curli biogensis.
2.17
2.18
(2009) Synergistic role of curli and cellulose in cell adherence and biofilm formation of attaching and effacing Escherichia coli and identification of Fis as a negative regulator of curli.
2.17
2.18
(2013) Structure, Function and Regulation of Outer Membrane Proteins Involved in Drug Transport in Enterobactericeae: the OmpFC - TolC Case.
1.9
2.14
(2022) Two-component systems regulate bacterial virulence in response to the host gastrointestinal environment and metabolic cues.
2.1
2.09
(2022) A Two-Component-System-Governed Regulon That Includes a beta-Lactamase Gene is Responsive to Cell Envelope Disturbance.
2.1
2.09
(2022) The sbiTRS Operon Contributes to Stenobactin-Mediated Iron Utilization in Stenotrophomonas maltophilia.
2.07
2.06
(2023) CsgI (YccT) Is a Novel Inhibitor of Curli Fimbriae Formation in Escherichia coli Preventing CsgA Polymerization and Curli Gene Expression.
1.84
2.04
(2022) Roles of Two-Component Signal Transduction Systems in Shigella Virulence.
1.82
2.02
(2020) Metabolic Activation of CsgD in the Regulation of Salmonella Biofilms.
2.05
2.01
(2022) Prevalence and Implications of Shiga Toxin-Producing E. coli in Farm and Wild Ruminants.
2.52
1.99
(2019) Contribution of the Cpx envelope stress system to metabolism and virulence regulation in Salmonella enterica serovar Typhimurium.
1.69
1.98
(2021) Genome-Wide Identification of Genes Involved in Acid Stress Resistance of Salmonella Derby.
2.02
1.97
(2017) Dual Regulation of the Small RNA MicC and the Quiescent Porin OmpN in Response to Antibiotic Stress in Escherichia coli.
2.02
1.97
(2014) Curli biogenesis: order out of disorder.
2.0
1.94
(2010) Asymmetric cross-regulation between the nitrate-responsive NarX-NarL and NarQ-NarP two-component regulatory systems from Escherichia coli K-12.
2.0
1.94
(2020) bolA gene involved in curli amyloids and fimbriae production in E. coli: exploring pathways to inhibit biofilm and amyloid formation.
1.97
1.92
(2012) Reduced set of virulence genes allows high accuracy prediction of bacterial pathogenicity in humans.
1.97
1.92
(2017) Envelope Stress Responses: An Interconnected Safety Net.
1.76
1.91
(2012) A connecter-like factor, CacA, links RssBRpoS and the CpxRCpxA two-component system in Salmonella.
1.76
1.91
(2023) The two-component system histidine kinase EnvZ contributes to Avian pathogenic Escherichia coli pathogenicity by regulating biofilm formation and stress responses.
1.95
1.9
(2010) Physiologically relevant small phosphodonors link metabolism to signal transduction.
1.95
1.9
(2020) Xenobiotic Effects of Chlorine Dioxide to Escherichia coli O157:H7 on Non-host Tomato Environment Revealed by Transcriptional Network Modeling: Implications to Adaptation and Selection.
1.93
1.87
(2018) The Broad-Spectrum Antimicrobial Potential of [Mn(CO)4(S2CNMe(CH2CO2H))], a Water-Soluble CO-Releasing Molecule (CORM-401): Intracellular Accumulation, Transcriptomic and Statistical Analyses, and Membrane Polarization.
1.93
1.87
(2016) Feedback Control of Two-Component Regulatory Systems.
1.93
1.87
(2022) Antibiofilm Action of Plant Terpenes in Salmonella Strains: Potential Inhibitors of the Synthesis of Extracellular Polymeric Substances.
1.89
1.81
(2009) Control of Salmonella pathogenicity island-2 gene expression.
1.89
1.81
(2023) CpxR promotes the carbapenem antibiotic resistance of Klebsiella pneumoniae by directly regulating the expression and the dissemination of blaKPC on the IncFII conjugative plasmid.
2.35
1.8
(2017) Fe(3+)-dependent epistasis between the CpxR-activated loci and the PmrA-activated LPS modification loci in Salmonella enterica.
2.35
1.8
(2018) Food-Associated Stress Primes Foodborne Pathogens for the Gastrointestinal Phase of Infection.
1.87
1.78
(2018) Regulatory Hierarchies Controlling Virulence Gene Expression in Shigella flexneri and Vibrio cholerae.
1.85
1.76
(2022) Transcriptional factor OmpR positively regulates prodigiosin biosynthesis in Serratia marcescens FZSF02 by binding with the promoter of the prodigiosin cluster.
2.28
1.74
(2021) The Effects of Natural Products and Environmental Conditions on Antimicrobial Resistance.
2.28
1.74
(2018) Contrasting silencing mechanisms of the same target mRNA by two regulatory RNAs in Escherichia coli.
1.84
1.73
(2021) Diversity in Sensing and Signaling of Bacterial Sensor Histidine Kinases.
1.82
1.7
(2014) Stress-induced remodeling of the bacterial proteome.
1.8
1.67
(2022) The Regulatory Circuit Underlying Downregulation of a Type III Secretion System in Yersinia enterocolitica by Transcription Factor OmpR.
2.22
1.67
(1986) Two-component regulatory systems responsive to environmental stimuli share strongly conserved domains with the nitrogen assimilation regulatory genes ntrB and ntrC.
2.17
1.61
(2023) A Dietary Source of High Level of Fluoroquinolone Tolerance in mcr-Carrying Gram-Negative Bacteria.
1.76
1.59
(2022) Systematic Identification of CpxRA-Regulated Genes and Their Roles in Escherichia coli Stress Response.
1.75
1.57
(2022) Clinical Escherichia coli: From Biofilm Formation to New Antibiofilm Strategies.
1.75
1.57
(2023) Long-term exposure to food-grade disinfectants causes cross-resistance to antibiotics in Salmonella enterica serovar Typhimurium strains with different antibiograms and sequence types.
2.13
1.56
(2015) Employing aromatic tuning to modulate output from two-component signaling circuits.
2.13
1.56
(2020) An Intertwined Network of Regulation Controls Membrane Permeability Including Drug Influx and Efflux in Enterobacteriaceae.
1.72
1.52
(2020) The role of the bacterial protease Prc in the uropathogenesis of extraintestinal pathogenic Escherichia coli.
1.72
1.52
(2009) Masters of conquest and pillage: Xenorhabdus nematophila global regulators control transitions from virulence to nutrient acquisition.
2.08
1.5
(2020) EnvZOmpR Two-Component Signaling: An Archetype System That Can Function Noncanonically.
1.69
1.49
(2021) How Can a Histidine Kinase Respond to Mechanical Stress?
2.05
1.46
(2007) Hierarchical classification of functionally equivalent genes in prokaryotes.
1.67
1.45
(2014) Biomolecular Mechanisms of Pseudomonas aeruginosa and Escherichia coli Biofilm Formation.
1.65
1.41
(2022) The VirF21:VirF30 protein ratio is affected by temperature and impacts Shigella flexneri host cell invasion.
2.01
1.4
(2018) Overexpression of Outer Membrane Protein X (OmpX) Compensates for the Effect of TolC Inactivation on Biofilm Formation and Curli Production in Extraintestinal Pathogenic Escherichia coli (ExPEC).
2.01
1.4
(2018) Role of SdiA on Biofilm Formation by Atypical Enteropathogenic Escherichia coli.
1.98
1.36
(2022) Characterization of the Role of Two-Component Systems in Antibiotic Resistance Formation in Salmonella enterica Serovar Enteritidis.
1.62
1.35
(2018) Discovery of New Genes Involved in Curli Production by a Uropathogenic Escherichia coli Strain from the Highly Virulent O45:K1:H7 Lineage.
1.62
1.35
(2019) Uropathogenic Escherichia coli employs both evasion and resistance to subvert innate immune-mediated zinc toxicity for dissemination.
1.95
1.33
(2023) Gram-negative bacteria resist antimicrobial agents by a DzrR-mediated envelope stress response.
1.9
1.25
(2022) Comparative Transcriptome Analysis Reveals Regulatory Factors Involved in Vibrio Parahaemolyticus Biofilm Formation.
1.9
1.25
(2020) Evolution of a New Function by Fusion between Phage DNA and a Bacterial Gene.
1.9
1.25
(2010) Two-component signaling circuit structure and properties.
1.9
1.25
(2020) Trans-Acting Small RNAs and Their Effects on Gene Expression in Escherichia coli and Salmonella enterica.
1.54
1.23
(2020) Functional determinants of a small protein controlling a broadly conserved bacterial sensor kinase.
1.87
1.23
(2017) Osmosensing by the bacterial PhoQPhoP two-component system.
1.87
1.23
(2016) The genes that encode the gonococcal transferrin binding proteins, TbpB and TbpA, are differentially regulated by MisR under iron-replete and iron-depleted conditions.
1.85
1.2
(2017) Small regulatory bacterial RNAs regulating the envelope stress response.
1.51
1.17
(1996) Macrophage killing is an essential virulence mechanism of Salmonella typhimurium.
2.65
1.16
(1982) Cloning of the regulatory locus ompB of Salmonella typhimurium LT-2. II. Identification of the envZ gene product, a protein involved in the expression of the porin proteins.
2.65
1.16
(2023) Universal structures for adaptation in biochemical reaction networks.
2.65
1.16
(1988) Deduced polypeptides encoded by the Bacillus subtilis sacU locus share homology with two-component sensor-regulator systems.
2.65
1.16
(2019) First-generation structure-activity relationship studies of 2,3,4,9-tetrahydro-1H-carbazol-1-amines as CpxA phosphatase inhibitors.
2.65
1.16
(2017) The CpxRCpxA system contributes to Salmonella gold-resistance by controlling the GolS-dependent gesABC transcription.
2.65
1.16
(2016) Developmental dynamics of the preterm infant gut microbiota and antibiotic resistome.
2.65
1.16
(2015) Development and validation of a high-throughput cell-based screen to identify activators of a bacterial two-component signal transduction system.
2.65
1.16
(2013) Outer membrane permeabilization is an essential step in the killing of gram-negative bacteria by the lectin RegIIIbeta.
2.65
1.16
(2009) The cysteine 354 and 277 residues of Salmonella enterica serovar Typhi EnvZ are determinants of autophosphorylation and OmpR phosphorylation.
2.65
1.16
(2002) Autoinduction of the ompR response regulator by acid shock and control of the Salmonella enterica acid tolerance response.
2.65
1.16
(2015) Analysis of the Salmonella regulatory network suggests involvement of SsrB and H-NS in sigma(E)-regulated SPI-2 gene expression.
1.49
1.15
(2018) Small Regulatory RNAs in the Enterobacterial Response to Envelope Damage and Oxidative Stress.
1.48
1.12
(2017) Signal transduction pathway mediated by the novel regulator LoiA for low oxygen tension induced Salmonella Typhimurium invasion.
1.78
1.11
(2012) Evolution of two-component signal transduction systems.
1.78
1.11
(2022) The Two-Component System CpxRA Represses Salmonella Pathogenicity Island 2 by Directly Acting on the ssrAB Regulatory Operon.
1.76
1.08
(2022) Bacterial Stress Responses as Potential Targets in Overcoming Antibiotic Resistance.
1.76
1.08
(2020) Membrane Vesicle Production as a Bacterial Defense Against Stress.
1.76
1.08
(2018) sRNA-dependent control of curli biosynthesis in Escherichia coli: McaS directs endonucleolytic cleavage of csgD mRNA.
1.76
1.08
(2017) To ~P or Not to ~P? Non-canonical activation by two-component response regulators.
1.76
1.08
(2016) A role for the bacterial GATC methylome in antibiotic stress survival.
1.76
1.08
(2023) Identification of cpxS mutational resistome in Pseudomonas aeruginosa.
2.47
1.08
(2023) An mRNA-Based Multiple Antigenic Gene Expression System Delivered by Engineered Salmonella for Severe Fever with Thrombocytopenia Syndrome and Assessment of Its Immunogenicity and Protection Using a Human DC-SIGN-Transduced Mouse Model.
2.47
1.08
(2022) The Microbiome and Gut Endocannabinoid System in the Regulation of Stress Responses and Metabolism.
2.47
1.08
(2019) The role of acid stress in Salmonella pathogenesis.
2.47
1.08
(1987) OmpR and EnvZ are pleiotropic regulatory proteins: positive regulation of the tripeptide permease (tppB) of Salmonella typhimurium.
2.47
1.08
(2015) Biophysical and physiological characterization of ZraP from Escherichia coli, the periplasmic accessory protein of the atypical ZraSR two-component system.
2.47
1.08
(2012) Regulation of Cu(I)Ag(I) efflux genes in Escherichia coli by the sensor kinase CusS.
2.47
1.08
(1991) The tus gene of Escherichia coli: autoregulation, analysis of flanking sequences and identification of a complementary system in Salmonella typhimurium.
2.47
1.08
(2008) What makes pathogens pathogenic.
2.47
1.08
(2007) Role of RpoS in fine-tuning the synthesis of Vi capsular polysaccharide in Salmonella enterica serotype Typhi.
2.47
1.08
(1990) Sequence of the pckA gene of Escherichia coli K-12: relevance to genetic and allosteric regulation and homology of E. coli phosphoenolpyruvate carboxykinase with the enzymes from Trypanosoma brucei and Saccharomyces cerevisiae.
2.47
1.08
(2004) Role of the two-component regulator CpxAR in the virulence of Salmonella enterica serotype Typhimurium.
2.47
1.08
Local Network Cluster (STRING)
Mixed, incl. DUF883, N-terminal domain, and NADPH-dependent FMN reductase
2.17
2.4
HPT domain superfamily, and Transcriptional regulatory protein WalR-like
2.14
2.38
SNARE associated Golgi protein
2.25
1.2
Mixed, incl. HPT domain superfamily, and Cellular response to phosphate starvation
2.1
1.11
Annotated Keywords (UniProt)
Two-component regulatory system
1.52
1.25
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