STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
UCREL1_6058DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1675 aa)    
Predicted Functional Partners:
UCREL1_11536
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]
   
 
 0.969
UCREL1_6151
Putative condensin subunit protein.
   
 
 0.934
UCREL1_1813
Putative ubiquitin-like modifier protein.
    
 0.906
UCREL1_6285
Putative sumo-conjugating enzyme ubc9 protein; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.846
UCREL1_9785
Putative dna repair protein.
   
 
 0.836
UCREL1_7905
Structural maintenance of chromosomes protein.
   
 
 0.820
UCREL1_5723
Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.
   
 
 0.815
UCREL1_3522
Putative thymidylate synthase protein.
  
  
 0.782
UCREL1_9718
Putative ubiquitin-conjugating enzyme protein; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.767
UCREL1_2597
Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
   
  
 0.759
Your Current Organism:
Eutypa lata
NCBI taxonomy Id: 1287681
Other names: E. lata UCREL1, Eutypa lata UCREL1
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