node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SEK40846.1 | SEK53327.1 | SAMN05443999_101371 | SAMN05443999_101610 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.991 |
SEK40846.1 | SEK97013.1 | SAMN05443999_101371 | SAMN05443999_10335 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Methylenetetrahydrofolate reductase (NADPH). | 0.940 |
SEK40846.1 | SEL80449.1 | SAMN05443999_101371 | SAMN05443999_10877 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Serine hydroxymethyltransferase. | 0.965 |
SEK40846.1 | fmt | SAMN05443999_101371 | SAMN05443999_11069 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.492 |
SEK40846.1 | glyA | SAMN05443999_101371 | SAMN05443999_104178 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.965 |
SEK40846.1 | purH | SAMN05443999_101371 | SAMN05443999_106182 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.507 |
SEK40846.1 | purN | SAMN05443999_101371 | SAMN05443999_101603 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Phosphoribosylglycinamide formyltransferase-1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.535 |
SEK40846.1 | thyX | SAMN05443999_101371 | SAMN05443999_104137 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.911 |
SEK53327.1 | SEK40846.1 | SAMN05443999_101610 | SAMN05443999_101371 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | 0.991 |
SEK53327.1 | SEK97013.1 | SAMN05443999_101610 | SAMN05443999_10335 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Methylenetetrahydrofolate reductase (NADPH). | 0.980 |
SEK53327.1 | SEL80449.1 | SAMN05443999_101610 | SAMN05443999_10877 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Serine hydroxymethyltransferase. | 0.920 |
SEK53327.1 | fmt | SAMN05443999_101610 | SAMN05443999_11069 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.916 |
SEK53327.1 | glyA | SAMN05443999_101610 | SAMN05443999_104178 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.920 |
SEK53327.1 | purH | SAMN05443999_101610 | SAMN05443999_106182 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.919 |
SEK53327.1 | purN | SAMN05443999_101610 | SAMN05443999_101603 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Phosphoribosylglycinamide formyltransferase-1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.920 |
SEK53327.1 | thyX | SAMN05443999_101610 | SAMN05443999_104137 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.909 |
SEK97013.1 | SEK40846.1 | SAMN05443999_10335 | SAMN05443999_101371 | Methylenetetrahydrofolate reductase (NADPH). | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | 0.940 |
SEK97013.1 | SEK53327.1 | SAMN05443999_10335 | SAMN05443999_101610 | Methylenetetrahydrofolate reductase (NADPH). | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.980 |
SEK97013.1 | SEL80449.1 | SAMN05443999_10335 | SAMN05443999_10877 | Methylenetetrahydrofolate reductase (NADPH). | Serine hydroxymethyltransferase. | 0.931 |
SEK97013.1 | fmt | SAMN05443999_10335 | SAMN05443999_11069 | Methylenetetrahydrofolate reductase (NADPH). | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.492 |