CCQ73219.1 protein (Magnetospira sp. QH2) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

Edges:

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

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[Homology]

Score

CCQ73219.1

Protein of unknown function. Similar to MGR_0442 protein from Magnetospirillum gryphiswaldense; No homology to any previously reported sequences. (1375 aa)

Predicted Functional Partners:

CCQ75403.1

0.773

CCQ74933.1

0.712

CCQ73042.1

0.704

CCQ74040.1

0.655

CCQ73052.1

0.630

CCQ73378.1

0.630

CCQ74742.1

0.613

CCQ75002.1

0.606

CCQ73220.1

0.586

CCQ72472.1

0.582

Your Current Organism:

Magnetospira sp. QH2

NCBI taxonomy Id: 1288970
Other names: M. sp. QH-2, Magnetospira sp. QH-2, marine magnetic spirillum QH-2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCQ72472.1	CCQ73052.1	MGMAQ_0503	MGMAQ_1119	Putative hemolysin-type calcium-binding region protein (fragment); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter.	Putative Flagellar hook protein FlgE; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative structure.	0.586
CCQ72472.1	CCQ73219.1	MGMAQ_0503	MGMAQ_1298	Putative hemolysin-type calcium-binding region protein (fragment); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter.	Protein of unknown function. Similar to MGR_0442 protein from Magnetospirillum gryphiswaldense; No homology to any previously reported sequences.	0.582
CCQ72472.1	CCQ73378.1	MGMAQ_0503	MGMAQ_1461	Putative hemolysin-type calcium-binding region protein (fragment); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter.	Putative Flagellin; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative structure.	0.473
CCQ72472.1	CCQ74040.1	MGMAQ_0503	MGMAQ_2150	Putative hemolysin-type calcium-binding region protein (fragment); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter.	Homologs of previously reported genes of unknown function.	0.706
CCQ72472.1	CCQ74742.1	MGMAQ_0503	MGMAQ_2896	Putative hemolysin-type calcium-binding region protein (fragment); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter.	Membrane protein of unknown function; No homology to any previously reported sequences.	0.685
CCQ72472.1	CCQ74933.1	MGMAQ_0503	MGMAQ_3097	Putative hemolysin-type calcium-binding region protein (fragment); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter.	Exported protein of unknown function; No homology to any previously reported sequences.	0.753
CCQ72472.1	CCQ75403.1	MGMAQ_0503	MGMAQ_3589	Putative hemolysin-type calcium-binding region protein (fragment); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter.	Conserved exported protein of unknown function with TPR repeats; Homologs of previously reported genes of unknown function.	0.745
CCQ73042.1	CCQ73052.1	MGMAQ_1109	MGMAQ_1119	Homologs of previously reported genes of unknown function.	Putative Flagellar hook protein FlgE; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative structure.	0.693
CCQ73042.1	CCQ73219.1	MGMAQ_1109	MGMAQ_1298	Homologs of previously reported genes of unknown function.	Protein of unknown function. Similar to MGR_0442 protein from Magnetospirillum gryphiswaldense; No homology to any previously reported sequences.	0.704
CCQ73042.1	CCQ74040.1	MGMAQ_1109	MGMAQ_2150	Homologs of previously reported genes of unknown function.	Homologs of previously reported genes of unknown function.	0.588
CCQ73042.1	CCQ74742.1	MGMAQ_1109	MGMAQ_2896	Homologs of previously reported genes of unknown function.	Membrane protein of unknown function; No homology to any previously reported sequences.	0.622
CCQ73042.1	CCQ74933.1	MGMAQ_1109	MGMAQ_3097	Homologs of previously reported genes of unknown function.	Exported protein of unknown function; No homology to any previously reported sequences.	0.514
CCQ73042.1	CCQ75403.1	MGMAQ_1109	MGMAQ_3589	Homologs of previously reported genes of unknown function.	Conserved exported protein of unknown function with TPR repeats; Homologs of previously reported genes of unknown function.	0.766
CCQ73052.1	CCQ72472.1	MGMAQ_1119	MGMAQ_0503	Putative Flagellar hook protein FlgE; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative structure.	Putative hemolysin-type calcium-binding region protein (fragment); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter.	0.586
CCQ73052.1	CCQ73042.1	MGMAQ_1119	MGMAQ_1109	Putative Flagellar hook protein FlgE; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative structure.	Homologs of previously reported genes of unknown function.	0.693
CCQ73052.1	CCQ73219.1	MGMAQ_1119	MGMAQ_1298	Putative Flagellar hook protein FlgE; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative structure.	Protein of unknown function. Similar to MGR_0442 protein from Magnetospirillum gryphiswaldense; No homology to any previously reported sequences.	0.630
CCQ73052.1	CCQ73378.1	MGMAQ_1119	MGMAQ_1461	Putative Flagellar hook protein FlgE; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative structure.	Putative Flagellin; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative structure.	0.788
CCQ73052.1	CCQ74040.1	MGMAQ_1119	MGMAQ_2150	Putative Flagellar hook protein FlgE; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative structure.	Homologs of previously reported genes of unknown function.	0.665
CCQ73052.1	CCQ74742.1	MGMAQ_1119	MGMAQ_2896	Putative Flagellar hook protein FlgE; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative structure.	Membrane protein of unknown function; No homology to any previously reported sequences.	0.528
CCQ73052.1	CCQ74933.1	MGMAQ_1119	MGMAQ_3097	Putative Flagellar hook protein FlgE; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative structure.	Exported protein of unknown function; No homology to any previously reported sequences.	0.433

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Network Stats

number of nodes:

11

number of edges:

17

average node degree:

3.09

avg. local clustering coefficient:

0.923

expected number of edges:

13

PPI enrichment p-value:

0.162

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006707

Cholesterol catabolic process

3 of 11

2.4

1.75

0.00053

GO:0006629

Lipid metabolic process

6 of 437

1.11

0.99

0.00055

GO:0006633

Fatty acid biosynthetic process

3 of 103

1.43

0.77

0.0220

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031177

Phosphopantetheine binding

3 of 29

1.98

1.22

0.0044

GO:0004315

3-oxoacyl-[acyl-carrier-protein] synthase activity

3 of 35

1.9

1.2

0.0044

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9435

Mixed, incl. GMC oxidoreductase, and Oxygen oxidoreductase covalent FAD-binding site

3 of 6

2.67

2.04

0.00018

CL:2969

Mixed, incl. DUF35 OB-fold domain, acyl-CoA-associated, and Thiolase

3 of 10

2.44

1.89

0.00030

CL:3441

ACP-like superfamily, and MbtH-like domain

3 of 55

1.7

1.09

0.0057

CL:3450

This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group., and Male sterility protein

2 of 11

2.23

1.07

0.0103

CL:3430

Mixed, incl. ACP-like superfamily, and Cytochrome P450

4 of 163

1.36

0.96

0.0053

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

kphy00984

Steroid degradation

3 of 17

2.21

2.0

0.00014

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0034081

Polyketide synthase complex

3 of 28

2.0

1.46

0.0014

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0001

2Fe-2S

2 of 9

2.31

1.14

0.0076

KW-0596

Phosphopantetheine

3 of 59

1.67

1.03

0.0076

KW-0408

Iron

3 of 160

1.24

0.6

0.0449

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00975

Thioesterase domain

3 of 9

2.49

1.98

0.00021

PF05199

GMC oxidoreductase

2 of 9

2.31

0.83

0.0295

PF00111

2Fe-2S iron-sulfur cluster binding domain

2 of 11

2.23

0.83

0.0295

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001031

Thioesterase

3 of 12

2.37

1.61

0.0010

IPR006162

Phosphopantetheine attachment site

3 of 29

1.98

1.17

0.0056

IPR020806

Polyketide synthase, phosphopantetheine-binding domain

3 of 35

1.9

1.12

0.0064

IPR007867

Glucose-methanol-choline oxidoreductase, C-terminal

2 of 9

2.31

0.88

0.0239

IPR000172

Glucose-methanol-choline oxidoreductase, N-terminal

2 of 9

2.31

0.88

0.0239

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00823

Phosphopantetheine attachment site

3 of 20

2.14

1.81

0.00031

SM00826

PKS_DH

2 of 11

2.23

1.13

0.0078

SM00825

Beta-ketoacyl synthase

2 of 12

2.19

1.13

0.0078

SM00822

This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group.

2 of 14

2.12

1.12

0.0078

SM00827

Acyl transferase domain in polyketide synthase (PKS) enzymes.

2 of 15

2.09

1.11

0.0078

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