STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KRK70458.1Hypothetical protein. (173 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.877
KRK73221.1
Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family.
     
 0.729
KRK70343.1
Acetaldehyde dehydrogenase (acetylating); In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
  
 
 0.584
tdk
Thymidine kinase.
  
 
 0.575
KRK70981.1
Alcohol dehydrogenase.
 
    0.573
KRK70457.1
Phospholipid-binding protein.
       0.565
KRK72479.1
Succinate-semialdehyde dehydrogenase (NADP+); Belongs to the aldehyde dehydrogenase family.
  
 
 0.544
KRK73299.1
ComE operon protein 2.
  
 
 0.541
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.527
fhs
Formyltetrahydrofolate synthetase; Belongs to the formate--tetrahydrofolate ligase family.
  
 
 0.518
Your Current Organism:
Lactobacillus nasuensis
NCBI taxonomy Id: 1291734
Other names: L. nasuensis JCM 17158, Lactobacillus nasuensis JCM 17158, Lactobacillus nasuensis SU 18, Lactobacillus sp. SU 18
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.