KRK73907.1 protein (Lactobacillus nasuensis)

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

KRK73907.1

6-phospho-beta-glucosidase; Belongs to the glycosyl hydrolase 1 family. (483 aa)

Predicted Functional Partners:

KRK73997.1

0.992

KRK71062.1

0.982

KRK71741.1

0.928

KRK73906.1

0.886

KRK73905.1

0.854

xylB

0.783

KRK70534.1

0.743

KRK73861.1

0.741

KRK70392.1

0.740

KRK73851.1

0.730

Your Current Organism:

Lactobacillus nasuensis

NCBI taxonomy Id: 1291734
Other names: L. nasuensis JCM 17158, Lactobacillus nasuensis JCM 17158, Lactobacillus nasuensis SU 18, Lactobacillus sp. SU 18

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KRK70392.1	KRK70534.1	FD02_GL000457	FD02_GL000605	Hypothetical protein.	Hypothetical protein.	0.993
KRK70392.1	KRK71062.1	FD02_GL000457	FD02_GL000247	Hypothetical protein.	Sucrose-specific PTS system IIBC component.	0.702
KRK70392.1	KRK73851.1	FD02_GL000457	FD02_GL001681	Hypothetical protein.	Cellobiose-specific PTS system IIC component.	0.967
KRK70392.1	KRK73907.1	FD02_GL000457	FD02_GL001737	Hypothetical protein.	6-phospho-beta-glucosidase; Belongs to the glycosyl hydrolase 1 family.	0.740
KRK70392.1	KRK73997.1	FD02_GL000457	FD02_GL001831	Hypothetical protein.	PTS system beta-glucoside-specific EIIBCA component.	0.702
KRK70534.1	KRK70392.1	FD02_GL000605	FD02_GL000457	Hypothetical protein.	Hypothetical protein.	0.993
KRK70534.1	KRK71062.1	FD02_GL000605	FD02_GL000247	Hypothetical protein.	Sucrose-specific PTS system IIBC component.	0.475
KRK70534.1	KRK73851.1	FD02_GL000605	FD02_GL001681	Hypothetical protein.	Cellobiose-specific PTS system IIC component.	0.989
KRK70534.1	KRK73861.1	FD02_GL000605	FD02_GL001691	Hypothetical protein.	Cellobiose-specific PTS system IIA component.	0.998
KRK70534.1	KRK73907.1	FD02_GL000605	FD02_GL001737	Hypothetical protein.	6-phospho-beta-glucosidase; Belongs to the glycosyl hydrolase 1 family.	0.743
KRK70534.1	KRK73997.1	FD02_GL000605	FD02_GL001831	Hypothetical protein.	PTS system beta-glucoside-specific EIIBCA component.	0.475
KRK71062.1	KRK70392.1	FD02_GL000247	FD02_GL000457	Sucrose-specific PTS system IIBC component.	Hypothetical protein.	0.702
KRK71062.1	KRK70534.1	FD02_GL000247	FD02_GL000605	Sucrose-specific PTS system IIBC component.	Hypothetical protein.	0.475
KRK71062.1	KRK71741.1	FD02_GL000247	FD02_GL001985	Sucrose-specific PTS system IIBC component.	Mannose-6-phosphate isomerase; Belongs to the mannose-6-phosphate isomerase type 1 family.	0.985
KRK71062.1	KRK73851.1	FD02_GL000247	FD02_GL001681	Sucrose-specific PTS system IIBC component.	Cellobiose-specific PTS system IIC component.	0.471
KRK71062.1	KRK73861.1	FD02_GL000247	FD02_GL001691	Sucrose-specific PTS system IIBC component.	Cellobiose-specific PTS system IIA component.	0.702
KRK71062.1	KRK73906.1	FD02_GL000247	FD02_GL001736	Sucrose-specific PTS system IIBC component.	Glycoside hydrolase family 3 protein.	0.489
KRK71062.1	KRK73907.1	FD02_GL000247	FD02_GL001737	Sucrose-specific PTS system IIBC component.	6-phospho-beta-glucosidase; Belongs to the glycosyl hydrolase 1 family.	0.982
KRK71062.1	KRK73997.1	FD02_GL000247	FD02_GL001831	Sucrose-specific PTS system IIBC component.	PTS system beta-glucoside-specific EIIBCA component.	0.999
KRK71062.1	xylB	FD02_GL000247	FD02_GL001734	Sucrose-specific PTS system IIBC component.	Xylose kinase.	0.466

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

21

average node degree:

3.82

avg. local clustering coefficient:

0.868

expected number of edges:

15

PPI enrichment p-value:

0.0894

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006760

Folic acid-containing compound metabolic process

5 of 17

2.42

3.72

5.38e-08

GO:0006730

One-carbon metabolic process

5 of 18

2.4

3.7

5.38e-08

GO:0046653

Tetrahydrofolate metabolic process

4 of 11

2.52

3.21

7.93e-07

GO:0006544

Glycine metabolic process

4 of 11

2.52

3.21

7.93e-07

GO:0035999

Tetrahydrofolate interconversion

3 of 6

2.65

2.48

2.53e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016742

Hydroxymethyl-, formyl- and related transferase activity

5 of 8

2.75

4.74

1.17e-09

GO:0016646

Oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

3 of 14

2.29

1.82

0.00036

GO:0016741

Transferase activity, transferring one-carbon groups

6 of 193

1.45

1.69

2.02e-05

GO:0070905

Serine binding

2 of 2

2.96

1.42

0.0027

GO:0004488

Methylenetetrahydrofolate dehydrogenase (NADP+) activity

2 of 2

2.96

1.42

0.0027

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:11971

Glycine metabolic process, and Tetrahydrofolate dehydrogenase/cyclohydrolase

6 of 11

2.69

5.87

4.98e-12

CL:11967

Purine ribonucleoside monophosphate biosynthesis, and Folic acid-containing compound metabolic process

7 of 32

2.3

5.31

4.98e-12

CL:11867

Metabolism of nucleotides, and Folic acid-containing compound metabolic process

8 of 82

1.94

4.44

4.98e-12

CL:11973

Glycine catabolic process, and Serine binding

4 of 6

2.78

4.0

3.56e-08

CL:12211

Aminoacyl-tRNA biosynthesis

3 of 41

1.82

1.29

0.0025

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00670

One carbon pool by folate

8 of 27

2.43

7.31

2.51e-16

map00970

Aminoacyl-tRNA biosynthesis

3 of 56

1.68

1.24

0.0024

map00450

Selenocompound metabolism

2 of 21

1.93

1.11

0.0071

map00630

Glyoxylate and dicarboxylate metabolism

3 of 81

1.52

1.06

0.0047

map00260

Glycine, serine and threonine metabolism

3 of 83

1.51

1.05

0.0047

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-196757

Metabolism of folate and pterines

5 of 27

2.22

3.42

1.06e-07

MAP-196849

Metabolism of water-soluble vitamins and cofactors

5 of 134

1.53

1.61

0.00010

MAP-196854

Metabolism of vitamins and cofactors

5 of 176

1.41

1.38

0.00025

MAP-71262

Carnitine synthesis

2 of 7

2.41

1.11

0.0093

MAP-1430728

Metabolism

9 of 2261

0.56

0.39

0.0108

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0554

One-carbon metabolism

2 of 6

2.48

1.15

0.0077

KW-0489

Methyltransferase

3 of 114

1.38

0.7

0.0304

KW-0663

Pyridoxal phosphate

2 of 39

1.67

0.68

0.0475

KW-0030

Aminoacyl-tRNA synthetase

2 of 36

1.7

0.68

0.0475

KW-0808

Transferase

5 of 624

0.86

0.5

0.0304

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02882

Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain

2 of 2

2.96

1.19

0.0071

PF00763

Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain

2 of 2

2.96

1.19

0.0071

PF00551

Formyl transferase

2 of 2

2.96

1.19

0.0071

PF00464

Serine hydroxymethyltransferase

2 of 2

2.96

1.19

0.0071

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR041872

Methionyl-tRNA synthetase, anticodon-binding domain

2 of 3

2.78

0.94

0.0200

IPR039429

Serine hydroxymethyltransferase-like domain

2 of 2

2.96

0.94

0.0200

IPR036477

Formyl transferase, N-terminal domain superfamily

2 of 3

2.78

0.94

0.0200

IPR033911

Methioninyl-tRNA synthetase core domain

2 of 2

2.96

0.94

0.0200

IPR020631

Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain

2 of 2

2.96

0.94

0.0200

(more ...)

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