STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
BAP84694.1Cystathionine beta-lyase; Gene_114; identified by MetaGeneAnnotator; putative. (382 aa)    
Predicted Functional Partners:
metC
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of..; cd00614; COG: COG0626; Cys/Met metabolism PLP-dependent enzyme; pfam01053; catalytic residue [active]; cystathionine beta-lyase / cystathionine gamma-lyase [Lactobacillus salivarius ATCC 11741]; gene_366; homodimer interface [polypeptide binding]; identified by MetaGeneAnnotator; putative; pyridoxal 5'-phosphate binding site [chemical binding] [...]
 
 
 0.940
BAP86739.1
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of..; cd00614; Cys/Met metabolism PLP-dependent enzyme; pfam01053; KEGG: lki:LKI_03365 2.3e-122 cystathionine beta-lyase; K01760 cystathionine beta-lyase; Psort location: Cytoplasmic, score: 9.97; catalytic residue [active]; cystathionine beta-lyase [Lactobacillus parafarraginis F0439]; gene_2159; homodimer interface [polypeptide binding]; identifie [...]
 
 
 0.939
cysK
Cysteine synthase; CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; cd01561; Cysteine synthase [Amino acid transport and metabolism]; COG0031; KEGG: lrl:pLC705_00039 4.1e-139 cysK; cysteine synthase (beta-pyrazolylalanine synthase) (beta-PA/CSase) (L-mimosine synthase) (O-acetylserine sulfhydrylase) (CSase) (OAS-TL); K01738 cysteine synthase A; Psort location: Cytoplasmic, score: 9.26; O-ac [...]
    
 0.923
BAP85937.1
O-acetylhomoserine aminocarboxypropyltransferase; CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of..; cd00614; O-acetylhomoserine sulfhydrylase / O-succinylhomoserine sulfhydrylase [Dehalobacter sp. CF]; OAH/OAS sulfhydrylase; TIGR01326; catalytic residue [active]; gene_1357; homodimer interface [polypeptide binding]; identified by MetaGeneAnnotator; putative; pyridoxal 5'-phosphate binding sit [...]
   
 0.917
BAP86738.1
O-acetylhomoserine aminocarboxypropyltransferase; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the..; cl00321; COG2873 O-acetylhomoserine sulfhydrylase; Cysteine synthase [Lactobacillus coryniformis subsp. coryniformis KCTC 3167]; O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; COG2873; catalytic residue [active]; gene_2158; identified by MetaGeneAnnotator; putati [...]
   
 0.917
BAP84678.1
Methionine synthase II (cobalamin-independent); CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme..; cd03311; THF binding site; gene_98; identified by MetaGeneAnnotator; putative; methionine synthase II (cobalamin-independent) [Oenococcus oeni PSU- 1]; substrate binding site [chemical binding]; zinc-binding site [ion binding].
    
  0.900
BAP85279.1
CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme..; cd03311; COG: COG0620; Pfam: PF01717; THF binding site; gene_699; identified by MetaGeneAnnotator; putative; substrate binding site [chemical binding]; vitamin-B12 independent methionine synthase [Lactobacillus antri DSM 16041]; zinc-binding site [ion binding].
    
  0.900
BAP85281.1
5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase [Lactobacillus reuteri MM2- 3]; CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme..; cd03311; COG: COG0620; THF binding site; gene_701; identified by MetaGeneAnnotator; putative; partial; substrate binding site [chemical binding]; zinc-binding site [ion binding].
    
  0.900
luxS
S-ribosylhomocysteinase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.
     
  0.900
metE
5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
    
  0.900
Your Current Organism:
Lactobacillus hokkaidonensis
NCBI taxonomy Id: 1291742
Other names: L. hokkaidonensis JCM 18461, Lactobacillus hokkaidonensis JCM 18461, Lactobacillus hokkaidonensis LOOC260, Lactobacillus sp. LOOC260
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