STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BAP84936.1NAD-dependent deacetylase; COG: COG0846; NAD+ binding site [chemical binding]; NAD-dependent deacetylase (regulatory protein SIR2 family protein) [Lactobacillus vaginalis ATCC 49540]; NAD-dependent deacetylase; Provisional; SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone..; cd01411; gene_356; identified by MetaGeneAnnotator; putative; putative Zn binding site [ion binding]; substrate b [...] (232 aa)    
Predicted Functional Partners:
nadD
Nicotinic acid mononucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
   
 0.928
nadE
NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family.
    
 0.922
deoD
KEGG: lbr:LVIS_1593 9.2e-87 deoD; purine nucleoside phosphorylase; K03784 purine-nucleoside phosphorylase; Psort location: Cytoplasmic, score: 9.97; Uridine phosphorylase [Nucleotide transport and metabolism]; COG2820; gene_1826; identified by MetaGeneAnnotator; putative; purine nucleoside phosphorylase [Lactobacillus kisonensis F0435]; purine nucleoside phosphorylase; Reviewed; PRK05819.
    
 0.922
nadK
Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
 
 0.919
BAP86329.1
Pyrophosphatase; Gene_1749; identified by MetaGeneAnnotator; putative.
    
  0.908
pntA
NAD(P) transhydrogenase subunit alpha; Alanine dehydrogenase/PNT, C-terminal domain; smart01002; Alanine dehydrogenase/PNT, N-terminal domain; smart01003; NAD(P) transhydrogenase subunit alpha [Lactobacillus buchneri CD034]; NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; COG3288; gene_1010; identified by MetaGeneAnnotator; putative.
     
 0.905
pntA-2
NAD(P) transhydrogenase subunit alpha; Domain of unknown function (DUF3814); pfam12769; KEGG: bla:BLA_1417 7.9e-26 NAD/NADP transhydrogenase alpha subunit; K00324 NAD(P) transhydrogenase subunit alpha; Psort location: CytoplasmicMembrane, score: 10.00; NAD(P)(+) transhydrogenase, alpha-2 subunit family protein [Lactobacillus parafarraginis F0439]; gene_1011; identified by MetaGeneAnnotator; putative.
     
 0.905
BAP86491.1
COG1957 Inosine-uridine nucleoside N-ribohydrolase; NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These..; cd02650; gene_1911; identified by MetaGeneAnnotator; putative; pyrimidine-specific ribonucleoside hydrolase [Leuconostoc gelidum JB7].
   
 
 0.904
pntB
NAD(P) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.
    
  0.901
BAP84658.1
Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; pfam02812; NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; cd05313; NAD(P) binding site [chemical binding]; gene_78; glutamate dehydrogenase [Lactobacillus rhamnosus GG]; glutamate dehydrogenase; Provisional; identified by MetaGeneAnnotator; putative; strain coidentity: ATCC 53103 = GG; synonym: Lactobacillus rhamnosus ATCC 53103; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
   
 0.871
Your Current Organism:
Lactobacillus hokkaidonensis
NCBI taxonomy Id: 1291742
Other names: L. hokkaidonensis JCM 18461, Lactobacillus hokkaidonensis JCM 18461, Lactobacillus hokkaidonensis LOOC260, Lactobacillus sp. LOOC260
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