STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cysKCysteine synthase; CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; cd01561; Cysteine synthase [Amino acid transport and metabolism]; COG0031; KEGG: lrl:pLC705_00039 4.1e-139 cysK; cysteine synthase (beta-pyrazolylalanine synthase) (beta-PA/CSase) (L-mimosine synthase) (O-acetylserine sulfhydrylase) (CSase) (OAS-TL); K01738 cysteine synthase A; Psort location: Cytoplasmic, score: 9.26; O-ac [...] (303 aa)    
Predicted Functional Partners:
BAP84947.1
CoA binding site [chemical binding]; Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of..; cd03354; gene_367; identified by MetaGeneAnnotator; putative; serine O-acetyltransferase [Oenococcus oeni PSU-1]; serine O-acetyltransferase; TIGR01172; substrate binding site [chemical binding]; trimer interface [polypeptide binding].
 
 0.998
metC
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of..; cd00614; COG: COG0626; Cys/Met metabolism PLP-dependent enzyme; pfam01053; catalytic residue [active]; cystathionine beta-lyase / cystathionine gamma-lyase [Lactobacillus salivarius ATCC 11741]; gene_366; homodimer interface [polypeptide binding]; identified by MetaGeneAnnotator; putative; pyridoxal 5'-phosphate binding site [chemical binding] [...]
 0.995
BAP86739.1
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of..; cd00614; Cys/Met metabolism PLP-dependent enzyme; pfam01053; KEGG: lki:LKI_03365 2.3e-122 cystathionine beta-lyase; K01760 cystathionine beta-lyase; Psort location: Cytoplasmic, score: 9.97; catalytic residue [active]; cystathionine beta-lyase [Lactobacillus parafarraginis F0439]; gene_2159; homodimer interface [polypeptide binding]; identifie [...]
 0.977
cysS
cysteinyl-tRNA synthetase; Anticodon-binding domain of cysteinyl tRNA synthetases; cd07963; HIGH motif; KMSKS motif; anticodon binding site; catalytic core domain of cysteinyl tRNA synthetase; cd00672; cysteinyl-tRNA synthetase [Lactobacillus rhamnosus GG]; cysteinyl-tRNA synthetase; Validated; PRK00260; gene_438; identified by MetaGeneAnnotator; putative; strain coidentity: ATCC 53103 = GG; synonym: Lactobacillus rhamnosus ATCC 53103; tRNA binding surface [nucleotide binding]; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
 
 0.928
serC
Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine.
  
 
 0.926
BAP84694.1
Cystathionine beta-lyase; Gene_114; identified by MetaGeneAnnotator; putative.
    
 0.923
luxS
S-ribosylhomocysteinase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.
 
 
 0.914
gshF
Glutathione biosynthesis bifunctional protein GshF; Synthesizes glutathione from L-glutamate and L-cysteine via gamma-L-glutamyl-L-cysteine; In the N-terminal section; belongs to the glutamate--cysteine ligase type 1 family. Type 2 subfamily.
    
 0.871
BAP85937.1
O-acetylhomoserine aminocarboxypropyltransferase; CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of..; cd00614; O-acetylhomoserine sulfhydrylase / O-succinylhomoserine sulfhydrylase [Dehalobacter sp. CF]; OAH/OAS sulfhydrylase; TIGR01326; catalytic residue [active]; gene_1357; homodimer interface [polypeptide binding]; identified by MetaGeneAnnotator; putative; pyridoxal 5'-phosphate binding sit [...]
 
 
 0.838
BAP86738.1
O-acetylhomoserine aminocarboxypropyltransferase; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the..; cl00321; COG2873 O-acetylhomoserine sulfhydrylase; Cysteine synthase [Lactobacillus coryniformis subsp. coryniformis KCTC 3167]; O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; COG2873; catalytic residue [active]; gene_2158; identified by MetaGeneAnnotator; putati [...]
 
 
 0.835
Your Current Organism:
Lactobacillus hokkaidonensis
NCBI taxonomy Id: 1291742
Other names: L. hokkaidonensis JCM 18461, Lactobacillus hokkaidonensis JCM 18461, Lactobacillus hokkaidonensis LOOC260, Lactobacillus sp. LOOC260
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